α-trifluoromethylated acyloins induce apoptosis in human oral tumor cell lines

被引：43

作者：

Kawase, M

Sakagami, H

Kusama, K

Motohashi, N

Saito, S

机构：

[1] Josai Univ, Fac Pharmaceut Sci, Sakado, Saitama 3500295, Japan

[2] Meikai Univ, Dept Dent Pharmacol, Sch Dent, Sakado, Saitama 3500283, Japan

[3] Meikai Univ, Dept Oral Pathol, Sch Dent, Sakado, Saitama 3500283, Japan

[4] Meiji Pharmaceut Univ, Tokyo 2048588, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(99)00548-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cytotoxic activity of newly synthesized trifluoromethyl ketones and related compounds was studied using two human oral tumor cell lines (HSG and HSC-2). Among them, alpha-trifluoromethylacyloins (1 and 2) were found to induce apoptotic cell death, as judged by the terminal deoxynucleotidyl transferase (TdT) dUTP nick end-labeling (TUNEL) method which detects DNA nick or fragments. Furthermore, the cytoplasm of 1 or 2 treated HSG cells was stained by M30 monoclonal antibody, which detects the product resulting from the cleavage of cytokeratin 18 by activated caspase. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：3113 / 3118

页数：6

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