Polysulfone-graft-poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes

被引：306

作者：

Park, JY ^{[1
]}

Acar, MH ^{[1
]}

Akthakul, A ^{[1
]}

Kuhlman, W ^{[1
]}

Mayes, AM ^{[1
]}

机构：

[1] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA

来源：

BIOMATERIALS | 2006年 / 27卷 / 06期

关键词：

polysulfone; polyethylene glycol; surface modification; protein resistance; membrane; dialysis;

D O I：

10.1016/j.biomaterials.2005.07.010

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Amphiphilic graft copolymers having polysulfone (PSf) backbones and poly(ethylene glycol) (PEG) side chains were synthesized via reaction of an alkoxide formed from PEG and a base (sodium hydride) with chloromethylated polysulfone. The resulting polysulfone-graft-poly(ethylene glycol), PSf-g-PEG, materials were hydrophilic but water insoluble, rendering them potentially useful as biomaterial coatings. PSf-g-PEG films exhibited high resistance to protein adsorption and cell attachment. When used as an additive in PSf membranes prepared by immersion precipitation, the graft copolymer preferentially segregates to the membrane surface, delivering enhanced wettability, porosity and protein resistance compared to unmodified PSf membranes. The surface properties of PSf-g-PEG modified membranes render them desirable candidates for hemodialysis. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：856 / 865

页数：10

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