Elevated chemokine concentrations in sera of human immunodeficiency virus (HIV)-seropositive and HIV-seronegative patients with tuberculosis: a possible role for mycobacterial lipoarabinomannan

被引：74

作者：

Juffermans, NP

Verbon, A

van Deventer, SJH

van Deutekom, H

Belisle, JT

Ellis, ME

Speelman, P

van der Poll, T

机构：

[1] Univ Amsterdam, Acad Med Ctr, Expt Med Lab, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands

[3] Municipal Hlth Serv, Dept TB, Amsterdam, Netherlands

[4] Colorado State Univ, Dept Microbiol, Ft Collins, CO 80523 USA

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 08期

关键词：

D O I：

10.1128/IAI.67.8.4295-4297.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Levels of interleukin 8 (IL-8), gamma interferon-inducible protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1 beta (MIP-1 beta) were elevated in patients with tuberculosis. IP-10 and MCP-1 levels were higher in human immunodeficiency virus (HIV)-seropositive patients than in HIV-seronegative patients with tuberculosis. Lipoarabinomannan induced IL-8, MCP-1, and MIP-1 beta in vitro, which was partly inhibited by anti-tumor necrosis factor antibody.

引用

页码：4295 / 4297

页数：3

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