Hypoxic effects on cholesterol metabolism of cultured rat aortic and brain microvascular endothelial cells, and aortic vascular smooth muscle cells

被引：3

作者：

Arai, Y

Sasaki, M

Sakuragawa, N

机构：

[1] Dept. of Inherited Metab. Diseases, National Institute of Neuroscience, Natl. Ctr. of Neurol. and Psychiatry

[2] Dept. of Inherited Metab. Diseases, National Institute of Neuroscience, Natl. Ctr. of Neurol. and Psychiatry, Kodaira, Tokyo 187

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1996年 / 180卷 / 01期

关键词：

hypoxia; cholesterol metabolism; brain microvascular endothelial cells; atherosclerosis;

D O I：

10.1620/tjem.180.17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated hypoxic effects on cholesterol metabolism in cultured brain microvascular endothelial cells (BEC), aortic endothelial cells (AEC) and aortic vascular smooth muscle cells (VSMC) from rat. In control conditions, acid lipase activities in BEC and AEC mere higher than that in VSMC. Acyl-Coenzyme A: cholesterol acyltransferase (ACAT) activities in control cells of BEC and AEC were lower than that of VSMC. Hypoxic treatment caused decreased acid lipase activity. ACAT activity decreased in VSMC. High pressure lipid chromatography (HPLC) study showed that hypoxia caused decreased contents of cholesterol and cholesteryl esters especially in AEC. We suggested that there is different cholesterol metabolism in the hypoxic treatment among endothelial cells and smooth muscle cells.

引用

页码：17 / 25

页数：9

共 21 条

[1] EFFECT OF HYPOXIA ON UPTAKE AND DEGRADATION OF LOW-DENSITY LIPOPROTEINS BY CULTURED HUMAN ARTERIAL SMOOTH-MUSCLE CELLS [J].