NMR assignment of human chemerin, a novel chemoattractant

被引:19
作者
Allen, Samantha J. [1 ]
Zabel, Brian A. [2 ,3 ]
Kirkpatrick, John [4 ]
Butcher, Eugene C. [2 ,3 ]
Nietlispach, Daniel [4 ]
Handel, Tracy M. [1 ]
机构
[1] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA
[2] Stanford Univ, Dept Pathol, Sch Med, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA
[3] Vet Affairs Palo Alto Hlth Care Syst, Ctr Mol Biol & Med, Palo Alto, CA 94304 USA
[4] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
基金
英国生物技术与生命科学研究理事会; 美国国家卫生研究院;
关键词
chemerin; chemotaxis; inflammation; CMKLR1;
D O I
10.1007/s12104-007-9047-7
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Chemerin is a potent chemoattractant for cells expressing the GPCR CMKLR1, and is thought to play important roles in cell migration and recruitment to sites of tissue damage and inflammation. Here we report the NMR assignments of the 15.6 kDa active form of uniformly N-15, C-13 labeled chemerin.
引用
收藏
页码:171 / 173
页数:3
相关论文
共 10 条
[1]   Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin [J].
Kulig, Paulina ;
Zabel, Brian A. ;
Dubin, Grzegorz ;
Alllen, Samantha J. ;
Ohyama, Takao ;
Potempa, Jan ;
Handel, Tracy M. ;
Butcher, Eugene C. ;
Cichy, Joanna .
JOURNAL OF IMMUNOLOGY, 2007, 178 (06) :3713-3720
[2]   Characterization of the human chemerin receptor -: ChemR23/CMKLR1 -: as co-receptor for human and simian immunodeficiency virus infection, and identification of virus-binding receptor domains [J].
Martensson, Ulrika E. A. ;
Fenyo, Eva Maria ;
Olde, Bjorn ;
Owman, Christer .
VIROLOGY, 2006, 355 (01) :6-17
[3]   Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23 [J].
Meder, W ;
Wendland, M ;
Busmann, A ;
Kutzleb, C ;
Spodsberg, N ;
John, H ;
Richter, R ;
Schleuder, D ;
Meyer, M ;
Forssmann, WG .
FEBS LETTERS, 2003, 555 (03) :495-499
[4]  
Samson M, 1998, EUR J IMMUNOL, V28, P1689, DOI 10.1002/(SICI)1521-4141(199805)28:05<1689::AID-IMMU1689>3.0.CO
[5]  
2-I
[6]   The CCPN data model for NMR spectroscopy: Development of a software pipeline [J].
Vranken, WF ;
Boucher, W ;
Stevens, TJ ;
Fogh, RH ;
Pajon, A ;
Llinas, P ;
Ulrich, EL ;
Markley, JL ;
Ionides, J ;
Laue, ED .
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 59 (04) :687-696
[7]   The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency [J].
Wittamer, V ;
Grégoire, F ;
Robberecht, P ;
Vassart, G ;
Communi, D ;
Parmentier, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (11) :9956-9962
[8]   Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids [J].
Wittamer, V ;
Franssen, JD ;
Vulcano, M ;
Mirjolet, JF ;
Le Poul, E ;
Migeotte, I ;
Brézillon, S ;
Tyldesley, R ;
Blanpain, C ;
Detheux, M ;
Montovani, A ;
Sozzani, S ;
Vassart, G ;
Parmentier, M ;
Communi, D .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (07) :977-985
[9]   Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades [J].
Zabel, BA ;
Allen, SJ ;
Kulig, P ;
Allen, JA ;
Cichy, J ;
Handel, TM ;
Butcher, EC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (41) :34661-34666
[10]   Chemokine-like receptor 1 expression and Chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood [J].
Zabel, BA ;
Silverio, AM ;
Butcher, EC .
JOURNAL OF IMMUNOLOGY, 2005, 174 (01) :244-251