Long Non-Coding RNAs Involved in Cancer Development and Cell Fate Determination

被引：107

作者：

Kitagawa, Masatoshi ^{[1
]}

Kotake, Yojiro ^{[2
]}

Ohhata, Tatsuya

机构：

[1] Hamamatsu Univ Sch Med, Dept Mol Biol, Higashi Ku, Hamamatsu, Shizuoka 4313125, Japan

[2] Kinki Univ, Fac Humanity Oriented Sci & Engn, Dept Biol & Environm Chem, Osaka, Japan

来源：

CURRENT DRUG TARGETS | 2012年 / 13卷 / 13期

关键词：

lncRNA; HOTAIR; ANRIL; Kcnq1ot1; Xist; polycomb; INK4; locus; human cancers; TUMOR-SUPPRESSOR GENE; BECKWITH-WIEDEMANN-SYNDROME; X-CHROMOSOME INACTIVATION; EARLY MOUSE EMBRYOS; XIST RNA; DOSAGE COMPENSATION; COLORECTAL CANCERS; BINDING PROTEINS; POOR-PROGNOSIS; ANRIL LOCUS;

D O I：

10.2174/138945012803530026

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The possible physiological significance of long non-coding RNAs (lncRNAs) has only recently been recognized. Technical innovations such as the super high-resolution tiling array and deep sequencing technology have indicated their importance. It has been proposed that lncRNAs such as HOTAIR are involved in the recruitment of chromatin modifiers to the target genes. The lncRNA ANRIL has been reported to be associated with a Polycomb complex, recruiting it to the target gene INK4 locus where it suppresses transcription via histone modification. Other lncRNAs such as Kcnq1ot1, AIR and Xist have also been found to recruit chromatin modifiers to their target loci. In this review, we discuss the function of lncRNAs such as HOTAIR, ANRIL, Kcnq1ot1, and Xist which recruit chromatin modifiers to target genes and discuss their involvement in cancer development and aggressiveness, and other cell fate determination.

引用

页码：1616 / 1621

页数：6

共 76 条

[1]

Context of change-X inactivation and disease [J].

Agrelo, Ruben ;

Wutz, Anton .

EMBO MOLECULAR MEDICINE, 2010, 2 (01) :6-15

[2]

ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome [J].

Arima, T ;

Kamikihara, T ;

Hayashida, T ;

Kato, K ;

Inoue, T ;

Shirayoshi, Y ;

Oshimura, M ;

Soejima, H ;

Mukai, T ;

Wake, N .

NUCLEIC ACIDS RESEARCH, 2005, 33 (08) :2650-2660

[3]

X chromosome inactivation in the cycle of life [J].

Barakat, Tahsin Stefan ;

Gribnau, Joost .

DEVELOPMENT, 2012, 139 (12) :2085-2089

[4]

Benoît MH, 2007, INT J ONCOL, V30, P5

[5]

Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p [J].

Broadbent, Helen M. ;

Peden, John F. ;

Lorkowski, Stefan ;

Goel, Anuj ;

Ongen, Halit ;

Green, Fiona ;

Clarke, Robert ;

Collins, Rory ;

Franzosi, Maria Grazia ;

Tognoni, Gianni ;

Seedorf, Udo ;

Rust, Stephan ;

Eriksson, Per ;

Hamsten, Anders ;

Farrall, Martin ;

Watkins, Hugh .

HUMAN MOLECULAR GENETICS, 2008, 17 (06) :806-814

[6]

The transcriptional landscape of the mammalian genome [J].

Carninci, P ;

Kasukawa, T ;

Katayama, S ;

Gough, J ;

Frith, MC ;

Maeda, N ;

Oyama, R ;

Ravasi, T ;

Lenhard, B ;

Wells, C ;

Kodzius, R ;

Shimokawa, K ;

Bajic, VB ;

Brenner, SE ;

Batalov, S ;

Forrest, ARR ;

Zavolan, M ;

Davis, MJ ;

Wilming, LG ;

Aidinis, V ;

Allen, JE ;

Ambesi-Impiombato, X ;

Apweiler, R ;

Aturaliya, RN ;

Bailey, TL ;

Bansal, M ;

Baxter, L ;

Beisel, KW ;

Bersano, T ;

Bono, H ;

Chalk, AM ;

Chiu, KP ;

Choudhary, V ;

Christoffels, A ;

Clutterbuck, DR ;

Crowe, ML ;

Dalla, E ;

Dalrymple, BP ;

de Bono, B ;

Della Gatta, G ;

di Bernardo, D ;

Down, T ;

Engstrom, P ;

Fagiolini, M ;

Faulkner, G ;

Fletcher, CF ;

Fukushima, T ;

Furuno, M ;

Futaki, S ;

Gariboldi, M .

SCIENCE, 2005, 309 (5740) :1559-1563

[7]

Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression [J].

Cunnington, Michael S. ;

Koref, Mauro Santibanez ;

Mayosi, Bongani M. ;

Burn, John ;

Keavney, Bernard .

PLOS GENETICS, 2010, 6 (04)

[8]

The Xist RNA A-repeat comprises a novel AUCG tetraloop fold and a platform for multimerization [J].

Duszczyk, Malgorzata M. ;

Wutz, Anton ;

Rybin, Vladimir ;

Sattler, Michael .

RNA, 2011, 17 (11) :1973-1982

[9]

Loss of the abundant nuclear non-coding RNA MALAT1 is compatible with life and development [J].

Eissmann, Moritz ;

Gutschner, Tony ;

Haemmerle, Monika ;

Guenther, Stefan ;

Caudron-Herger, Maiwen ;

Gross, Matthias ;

Schirmacher, Peter ;

Rippe, Karsten ;

Braun, Thomas ;

Zoernig, Martin ;

Diederichs, Sven .

RNA BIOLOGY, 2012, 9 (08) :1076-1087

[10]

Regulation of the INK4b-ARF-INK4a tumour suppressor locus:: all for one or one for all [J].

Gil, Jesus ;

Peters, Gordon .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (09) :667-677

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