Effect of folic acid supplementation during pregnancy on gestational hypertension/preeclampsia: A systematic review and meta-analysis

被引：42

作者：

Hua, Xiaolin ^{[1
,2
,3
]}

Zhang, Jiewen ^{[2
,3
,4
]}

Guo, Yanfang ^{[2
,3
]}

Shen, Minxue ^{[2
,3
,5
]}

Gaudet, Laura ^{[2
,3
]}

Janoudi, Ghayath ^{[6
]}

Walker, Mark ^{[2
,3
,7
]}

Wen, Shi Wu ^{[2
,3
,5
,7
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Obstet, Shanghai, Peoples R China

[2] Univ Ottawa, Dept Obstet & Gynecol, OMNI Res Grp, Fac Med, Ottawa, ON, Canada

[3] Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada

[4] Capital Med Univ, Beijing Friendship Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China

[5] Cent S Univ, Sch Publ Hlth, Changsha, Hunan, Peoples R China

[6] Canadian Agcy Drugs & Technol Hlth, Ottawa, ON, Canada

[7] Univ Ottawa, Fac Med, Sch Epidemiol Publ Hlth & Prevent Med, Ottawa, ON, Canada

来源：

HYPERTENSION IN PREGNANCY | 2016年 / 35卷 / 04期

关键词：

Folic acid; gestational hypertension; preeclampsia; supplementation; PERICONCEPTIONAL MULTIVITAMIN USE; NEURAL-TUBE DEFECTS; HOMOCYSTEINE LEVELS; REDUCED RISK; VITAMIN-C; PREECLAMPSIA; WOMEN; FORTIFICATION; HYPERTENSION; ASSOCIATION;

D O I：

10.1080/10641955.2016.1183673

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Objective: To evaluate the effect of folic acid supplementation during pregnancy on the risk of gestational hypertension/preeclampsia. Methods: A systematic review and meta-analysis were conducted. Medline, Embase, Scopus, and the Web of Science were searched from inception to December 2014. Results: Out of 1224 potentially relevant studies, 13 studies met our inclusion criteria (2 randomized controlled trials (RCTs), 10 cohort studies, and 1 case-control study). The pooled relative risk (RR) and 95% confidence interval (CI) of the two RCTs were 0.62 (0.45-0.87) in the trial arm as compared with the placebo arm. The pooled RR was 0.92 (95% CI: 0.79-1.08) for nine cohort studies with available data on folic acid supplementation in pregnancy and gestational hypertension/preeclampsia. Pooled RR was 0.88 (95% CI: 0.76-1.02) for eight cohort studies with available data on folic acid supplementation and preeclampsia. Conclusion: Whether folic acid supplementation in pregnancy can prevent the occurrence of gestational hypertension/preeclampsia remains uncertain.

引用

页码：447 / 460

页数：14

共 54 条

[1]

ACOG, 2002, OBSTET GYNECOL, V99, P869

[2]

Folic acid uptake by the human syncytiotrophoblast is affected by gestational diabetes, hyperleptinemia, and TNF-α [J].