Dietary precursors of trimethylamine in man: A pilot study

被引：194

作者：

Zhang, AQ ^{[1
]}

Mitchell, SC ^{[1
]}

Smith, RL ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Biomed Sci, London SW7 2AZ, England

来源：

FOOD AND CHEMICAL TOXICOLOGY | 1999年 / 37卷 / 05期

关键词：

trimethylamine; trimethylamine N-oxide; betaine; carnitine; choline; creatinine; lecithin; diet; human;

D O I：

10.1016/S0278-6915(99)00028-9

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

An increased urinary excretion of trimethylamine and its Ai-oxide were observed in man following the oral intake (15 mmol) of choline (63% dose as trimethylamine and its N-oxide), D,L-carnitine (31% dose) and trimethylamine N-oxide (78% dose). Similar ingestion of betaine, creatinine or lecithin failed to elicit any significant increases. Of 46 different foods investigated, only fish and other sea-products gave rise to significant increases in urinary trimethylamine and N-oxide. Ingestion of fruits, vegetables, cereal and dairy produce, and meats had no measurable effects. Reasons for the apparent lack of trimethylamine provision by foods previously thought to be precursors are given and the role of gut microflora highlighted. (C) 1999 Elsevier Science Ltd. Ali rights reserved.

引用

页码：515 / 520

页数：6

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