The pharmacokinetics and pharmacodynamics of Procysteine in amyotrophic lateral sclerosis

被引:25
作者
Cudkowicz, ME
Sexton, PM
Ellis, T
Hayden, DL
Gwilt, PR
Whalen, J
Brown, RH
机构
[1] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Day Neuromuscular Res Lab, Charlestown, MA USA
[3] Harvard Univ, Sch Med, MGH, Gen Clin Res Ctr, Boston, MA USA
[4] Univ Nebraska, Ctr Med, Coll Pharm, Dept Pharmaceut Sci, Omaha, NE 68198 USA
关键词
D O I
10.1212/WNL.52.7.1492
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In 13 subjects with ALS, we studied the safety and pharmacokinetic properties of Procysteine, a cysteine prodrug that increases levels of intracellular glutathione. We found that oral administration of Procysteine was safe. Procysteine enters CSF after both IV and oral dosing and accumulates to significant levels in CSF. We also observed that CSF levels of glutathione fall dramatically with aging.
引用
收藏
页码:1492 / 1494
页数:3
相关论文
共 10 条