Structural and functional neural correlates of visuospatial information processing in normal aging and amnestic mild cognitive impairment

被引：52

作者：

Alichniewicz, Karolina K. ^{[1
]}

Brunner, Florian ^{[1
]}

Kluenemann, Hans H. ^{[2
]}

Greenlee, Mark W. ^{[1
]}

机构：

[1] Univ Regensburg, Inst Expt Psychol, D-93040 Regensburg, Germany

[2] Univ Regensburg, Dept Psychiat Psychosomat & Psychotherapy, D-93040 Regensburg, Germany

来源：

NEUROBIOLOGY OF AGING | 2012年 / 33卷 / 12期

关键词：

Mild cognitive impairment; Alzheimer's disease; Functional magnetic resonance imaging; Working memory; Apolipoprotein E; Aging; ALZHEIMERS ASSOCIATION WORKGROUPS; VOXEL-BASED MORPHOMETRY; ADULT AGE-DIFFERENCES; GRAY-MATTER VOLUME; WORKING-MEMORY; APOLIPOPROTEIN-E; BRAIN ACTIVATION; INDIVIDUAL-DIFFERENCES; DIAGNOSTIC GUIDELINES; CORTICAL ACTIVATION;

D O I：

10.1016/j.neurobiolaging.2012.02.010

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Our understanding of cognitive changes related to human aging and their underlying neural processes is challenged by the distinction between normal and pathological aging. In our study, the neural correlates of visuospatial working memory (VSWM) in young persons (YC), healthy older adults (HC) and patients with amnestic mild cognitive impairment (aMCI) were investigated. Effects of the genetic risk factor apolipoprotein E (ApoE) epsilon 4 on a VSWM task were analyzed for HC and aMCI patients. Higher cortical activation in extrastriate occipital regions and significantly decreased brain volumes in frontoparietal areas were observed in HC compared with young persons. Also, reduced cortical activation in the right middle frontal gyrus and superior frontal gyrus was observed in aMCI-patients compared with HC. Thus, attenuated cortical activation during VSWM tasks is related to the formation of aMCI and may serve as an early marker for cognitive decline. In contrast to previous studies, no significant apolipoprotein E-linked differences were found between HC and aMCI groups. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：2782 / 2797

页数：16

共 124 条

[1]

Apolipoprotein E ε4 influences on episodic recall and brain structures in aging pilots [J].

Adamson, Maheen M. ;

Landy, Kelly M. ;

Duong, Susan ;

Fox-Bosetti, Sabrina ;

Ashford, J. Wesson ;

Murphy, Greer M. ;

Weiner, Michael ;

Taylor, Joy L. .

NEUROBIOLOGY OF AGING, 2010, 31 (06) :1059-1063

[2]

Visual and visuospatial short-term memory in mild cognitive impairment and Alzheimer disease: Role of attention [J].

Alescio-Lautier, B. ;

Michel, B. F. ;

Herrera, C. ;

Elahmadi, A. ;

Chambon, C. ;

Touzet, C. ;

Paban, V. .

NEUROPSYCHOLOGIA, 2007, 45 (08) :1948-1960

[3]

Revised criteria for mild cognitive impairment: Validation within a longitudinal population study [J].

Artero, Sylvaine ;

Petersen, Ronald ;

Touchon, Jacques ;

Ritchie, Karen .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2006, 22 (5-6) :465-470

[4]

Voxel-based morphometry - The methods [J].

Ashburner, J ;

Friston, KJ .

NEUROIMAGE, 2000, 11 (06) :805-821

[5]

Working memory [J].

Baddeley, Alan .

CURRENT BIOLOGY, 2010, 20 (04) :R136-R140

[6]

Working memory: Looking back and looking forward [J].

Baddeley, A .

NATURE REVIEWS NEUROSCIENCE, 2003, 4 (10) :829-839

[7]

THE DECLINE OF WORKING MEMORY IN ALZHEIMERS-DISEASE - A LONGITUDINAL-STUDY [J].

BADDELEY, AD ;

BRESSI, S ;

DELLASALA, S ;

LOGIE, R ;

SPINNLER, H .

BRAIN, 1991, 114 :2521-2542

[8]

The process of successful ageing [J].

Baltes, MM ;

Carstensen, LL .

AGEING & SOCIETY, 1996, 16 :397-422

[9]

ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain [J].

Bandaru, Veera Venkata Ratnam ;

Troncoso, Juan ;

Wheeler, David ;

Pletnikova, Olga ;

Wang, Jessica ;

Conant, Kathy ;

Haughey, Norman J. .

NEUROBIOLOGY OF AGING, 2009, 30 (04) :591-599

[10]

Mild cognitive impairment and Alzheimer's disease:: An investigation of the CERAD-NP test battery [J].

Barth, S ;

Schönknecht, P ;

Pantel, J ;

Schröder, J .

FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE, 2005, 73 (10) :568-576

← 1 2 3 4 5 6 7 8 9 10 →