Transcription - Oxygen sensing gets a second wind

被引：122

作者：

Bruick, RK ^{[1
]}

McKnight, SL ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

来源：

SCIENCE | 2002年 / 295卷 / 5556期

关键词：

D O I：

10.1126/science.1069825

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

引用

收藏

页码：807 / 808

页数：2

相关论文

共 16 条

[1]

A conserved family of prolyl-4-hydroxylases that modify HIF [J].

Bruick, RK ;

McKnight, SL .

SCIENCE, 2001, 294 (5545) :1337-1340

[2]

Role of HIF-1α or in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis [J].

Carmeliet, P ;

Dor, Y ;

Herbert, JM ;

Fukumura, D ;

Brusselmans, K ;

Dewerchin, M ;

Neeman, M ;

Bono, F ;

Abramovitch, R ;

Maxwell, P ;

Koch, CJ ;

Ratcliffe, P ;

Moons, L ;

Jain, RK ;

Collen, D ;

Keshet, E .

NATURE, 1998, 394 (6692) :485-490

[3]

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1α [J].

Carrero, P ;

Okamoto, K ;

Coumailleau, P ;

O'Brien, S ;

Tanaka, H ;

Poellinger, L .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (01) :402-415

[4]

Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia:: their stabilization and redox signal-induced interaction with CBP/p300 [J].

Ema, M ;

Hirota, K ;

Mimura, J ;

Abe, H ;

Yodoi, J ;

Sogawa, K ;

Poellinger, L ;

Fujii-Kuriyama, Y .

EMBO JOURNAL, 1999, 18 (07) :1905-1914

[5]

C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation [J].

Epstein, ACR ;

Gleadle, JM ;

McNeill, LA ;

Hewitson, KS ;

O'Rourke, J ;

Mole, DR ;

Mukherji, M ;

Metzen, E ;

Wilson, MI ;

Dhanda, A ;

Tian, YM ;

Masson, N ;

Hamilton, DL ;

Jaakkola, P ;

Barstead, R ;

Hodgkin, J ;

Maxwell, PH ;

Pugh, CW ;

Schofield, CJ ;

Ratcliffe, PJ .

CELL, 2001, 107 (01) :43-54

[6]

Molecular mechanism of hypoxia-inducible factor 1α-p300 interaction -: A leucine-rich interface regulated by a single cysteine [J].

Gu, J ;

Milligan, J ;

Huang, LE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (05) :3550-3554

[7]

Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway [J].

Huang, LE ;

Gu, J ;

Schau, M ;

Bunn, HF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) :7987-7992

[8]

HIFα targeted for VHL-mediated destruction by proline hydroxylation:: Implications for O2 sensing [J].

Ivan, M ;

Kondo, K ;

Yang, HF ;

Kim, W ;

Valiando, J ;

Ohh, M ;

Salic, A ;

Asara, JM ;

Lane, WS ;

Kaelin, WG .

SCIENCE, 2001, 292 (5516) :464-468

[9]

Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation [J].

Jaakkola, P ;

Mole, DR ;

Tian, YM ;

Wilson, MI ;

Gielbert, J ;

Gaskell, SJ ;

von Kriegsheim, A ;

Hebestreit, HF ;

Mukherji, M ;

Schofield, CJ ;

Maxwell, PH ;

Pugh, CW ;

Ratcliffe, PJ .

SCIENCE, 2001, 292 (5516) :468-472

[10]

Transactivation and inhibitory domains of hypoxia-inducible factor 1 alpha. Modulation of transcriptional activity by oxygen tension [J].

Jiang, BH ;

Zheng, JZ ;

Leung, SW ;

Roe, R ;

Semenza, GL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (31) :19253-19260