Integron-associated imipenem resistance in Acinetobacter baumannii isolated from a regional hospital in Taiwan

被引：33

作者：

Liu, SY

Lin, JY

Chu, C

Su, LH

Lin, TY

Chiu, CH ^{[1
]}

机构：

[1] Chang Gung Childrens Hosp, Dept Pediat, Taoyuan, Taiwan

[2] Da Yeh Univ, Dept Mol Biotechnol, Changhua, Taiwan

[3] Natl Chiayi Univ, Dept Appl Microbiol, Chiayi, Taiwan

[4] Chang Gung Mem Hosp, Dept Clin Pathol, Taoyuan, Taiwan

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2006年 / 27卷 / 01期

关键词：

integron; imipenem resistance; Acinetobacter baumannii;

D O I：

10.1016/j.ijantimicag.2005.09.010

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We investigated the genetic properties of imipenem-resistant Acinetobacter baumannii collected from a regional hospital in Taiwan. Pulsed-field gel electrophoresis demonstrated that the isolates were genetically diverse. Polymerase chain reaction, DNA sequencing, and DNA-DNA hybridisation showed that the bla(IMP-1) gene resided as a cassette in a plasmid-borne class I integron in two isolates. The majority of the resistant isolates were plasmid-less and carried no bla(IMP), bla(VIM) or bla(CFI) genes, indicating that other uncharacterised metallo-beta-lactamases or mechanisms other than enzyme production are involved in carbapenem resistance in this group of A. baumannii. We conclude that multidrug resistance of A. bauniannii was a combined effect of lateral gene transfer and clonal spread of multiple resistant clones. Strict measures should be implemented to control the further spread of resistance. (c) 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：81 / 84

页数：4

共 26 条

[1] Characterization of OXA-25, OXA-26, and OXA-27, molecular class D β-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii [J].