Successful Treatment of Alopecia Areata with Topical Calcipotriol

被引：56

作者：

Kim, Dong Ha ^{[1
]}

Lee, Jin Woong ^{[1
]}

Kim, In Su ^{[1
]}

Choi, Sun Young ^{[1
]}

Lim, Yun Young ^{[1
]}

Kim, Hyeong Mi ^{[1
]}

Kim, Beom Joon ^{[1
]}

Kim, Myeung Nam ^{[1
]}

机构：

[1] Chung Ang Univ, Coll Med, Dept Dermatol, Seoul 156756, South Korea

来源：

ANNALS OF DERMATOLOGY | 2012年 / 24卷 / 03期

关键词：

Alopecia areata; Calcipotriol; Therapeutics; Vitamin D; VITAMIN-D-RECEPTOR; 1,25-DIHYDROXYVITAMIN D-3; IN-VITRO; EXPRESSION; ANALOGS; SYSTEM; GENE;

D O I：

10.5021/ad.2012.24.3.341

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Alopecia areata (AA) is an inflammatory hair loss of unknown etiology. AA is chronic and relapsing, and no effective cure or preventive treatment has been established. Vitamin D was recently reported to be important in cutaneous immune modulation as well as calcium regulation and bone metabolism. It is well known that areata is common clinical finding in patients with vitamin D deficiency, vitamin D-resistant rickets, or vitamin D receptor (VDR) mutation. The biological actions of vitamin D3 derivatives include regulation of epidermal cell proliferation and differentiation and modulation of cytokine production. These effects might explain the efficacy of vitamin D3 derivatives for treating AA. In this study, we report a 7-year-old boy with reduced VDR expression in AA, recovery of whom was observed by topical application of calcipotriol, a strong vitamin D analog. (Ann Dermatol 24(3) 341 similar to 344, 2012)

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页码：341 / 344

页数：4

相关论文

共 16 条

[1]

Alopecia areata update Part II. Treatment [J].

Alkhalifah, Abdullah ;

Alsantali, Adel ;

Wang, Eddy ;

McElwee, Kevin J. ;

Shapiro, Jerry .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2010, 62 (02) :191-202

[2]

Vitamin D and autoimmunity: New aetiological and therapeutic considerations [J].

Arnson, Yoav ;

Amital, Howard ;

Shoenfeld, Yehuda .

ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (09) :1137-1142

[3]

1α,25-dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells [J].

Boonstra, A ;

Barrat, FJ ;

Crain, C ;

Heath, VL ;

Savelkoul, HFJ ;

O'Garra, A .

JOURNAL OF IMMUNOLOGY, 2001, 167 (09) :4974-4980

[4]

Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3 -: Involvement of NF-κB downregulation in transcriptional repression of the p40 gene [J].

D'Ambrosio, D ;

Cippitelli, M ;

Cocciolo, MG ;

Mazzeo, D ;

Di Lucia, P ;

Lang, R ;

Sinigaglia, F ;

Panina-Bordignon, P .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (01) :252-262

[5]

Two New Unrelated Cases of Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets with Alopecia Resulting from the Same Novel Nonsense Mutation in the Vitamin D Receptor Gene [J].

Forghani, Nikta ;

Lum, Catherine ;

Krishnan, Sowmya ;

Wang, Jining ;

Wilson, Darrel M. ;

Blackett, Piers R. ;

Malloy, Peter J. ;

Feldman, David .

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2010, 23 (08) :843-850

[6]

Dendritic cell modulation by 1α,25 dihydroxyvitamin D3 and its analogs:: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo [J].

Griffin, MD ;

Lutz, W ;

Phan, VA ;

Bachman, LA ;

McKean, DJ ;

Kumar, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6800-6805

[7]

Guidelines for the management of alopecia areata [J].

Hull, SPM ;

Wood, ML ;

Hutchinson, PE ;

Sladden, M ;

Messenger, AG .

BRITISH JOURNAL OF DERMATOLOGY, 2003, 149 (04) :692-699

[8]

Vitamin D3 and its synthetic analogs inhibit the spontaneous in vitro immunoglobulin production by SLE-derived PBMC [J].

Linker-Israeli, M ;

Elstner, E ;

Klinenberg, JR ;

Wallace, DJ ;

Koeffler, HP .

CLINICAL IMMUNOLOGY, 2001, 99 (01) :82-93

[9]

Prediction and prevention of autoimmune skin disorders [J].

Nancy, Agmon-Levin ;

Yehuda, Shoenfeld .

ARCHIVES OF DERMATOLOGICAL RESEARCH, 2009, 301 (01) :57-64

[10]

THE ROLE OF THE VITAMIN-D ENDOCRINE SYSTEM IN HEALTH AND DISEASE [J].

REICHEL, H ;

KOEFFLER, HP ;

NORMAN, AW .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (15) :980-991