Glucokinase is concentrated in insulin-secretory granules of pancreatic B-cells

被引：18

作者：

Toyoda, Y

Yoshie, S

Shironoguchi, H

Miwa, I ^{[1
]}

机构：

[1] Meijo Univ, Fac Pharm, Dept Pathobiochem, Tempaku Ku, Nagoya, Aichi 4688503, Japan

[2] Nippon Dent Univ, Sch Dent Niigata, Niigata 9518580, Japan

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 1999年 / 112卷 / 01期

关键词：

D O I：

10.1007/s004180050389

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We immunohistochemically examined the distribution of glucokinase (GK) in the B-cells of pancreatic islets of normal rats. GK was stained punctately in the cytoplasm of B-cells when examined under the light microscope. By use of a double-immunostaining technique, most of the GK immunoreactivity was observed to bie colocalized with insulin immunoreactivity. Electron microscopic examination by the immunogold method revealed that GK immunoreactivity was predominantly located within insulin-secretory granules of pancreatic B-cells.

引用

页码：35 / 40

页数：6

共 24 条

[1] GLUCOKINASE IN B-CELL-DEPLETED ISLETS OF LANGERHANS [J].