RNAi, heterochromatin and the cell cycle

被引：59

作者：

Kloc, Anna ^{[1
,2
]}

Martienssen, Robert ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[2] SUNY Stony Brook, Grad Program Genet, Stony Brook, NY 11794 USA

来源：

TRENDS IN GENETICS | 2008年 / 24卷 / 10期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/j.tig.2008.08.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

For many decades after its initial characterization, heterochromatin was considered to be transcriptionally inert, but newer work indicates that this highly condensed chromosomal material is transcribed, and rapidly silenced, by an orchestrated sequence of events directed by RNA interference (RNAi). Recent studies shed light on the timely assembly and inheritance of heterochromatin within a short period during the cell cycle, thereby providing an explanation for how 'silent' heterochromatin can be transcribed during the S phase of the cell cycle. Together, these findings suggest a model of RNAi-directed epigenetic inheritance.

引用

页码：511 / 517

页数：7

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