An efficient and versatile synthesis of piperazine-2-carboxamides

被引：47

作者：

Rossen, K

Sager, J

DiMichele, LM

机构：

[1] Department of Process Research, Merck Research Laboratories, Rahway, NJ 07065

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(97)00607-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and versatile synthesis of piperazine-2-carboxamides 5 is described. The preparation consists of a one-pot, 4-component Ugi condensation between an N-alkylethylenediamine 1, chloroacetaldehyde (2), an isonitrile 3 and a carboxylic acid 4. (C) 1997 Elsevier Science Ltd.

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收藏

页码：3183 / 3186

页数：4

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