Cellular functions depend on numerous protein-coding and noncoding RNAs and the RNA-binding proteins associated with them, which form ribonucleoprotein complexes (RNPs). Mutations that disrupt either the RNA or protein components of RNPs or the factors required for their assembly can be deleterious. Alternative splicing provides cells with an exquisite capacity to fine-tune their transcriptome and proteome in response to cues. Splicing depends on a complex code, numerous RNA-binding proteins, and an enormously intricate network of interactions among them, increasing the opportunity for exposure to mutations and misregulation that cause disease. The discovery of disease-causing mutations in RNAs is yielding a wealth of new therapeutic targets, and the growing understanding of RNA biology and chemistry is providing new RNA-based tools for developing therapeutics.
机构:
Univ Iowa, Dept Internal Med, Iowa City, IA 52240 USA
Univ Iowa, Dept Mol Physiol & Biophys, Iowa City, IA 52240 USAUniv Iowa, Dept Internal Med, Iowa City, IA 52240 USA
Boudreau, Ryan L.
Martins, Ines
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机构:
Univ Iowa, Dept Internal Med, Iowa City, IA 52240 USAUniv Iowa, Dept Internal Med, Iowa City, IA 52240 USA
Martins, Ines
Davidson, Beverly L.
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Univ Iowa, Dept Internal Med, Iowa City, IA 52240 USA
Univ Iowa, Dept Mol Physiol & Biophys, Iowa City, IA 52240 USA
Univ Iowa, Dept Neurol, Iowa City, IA 52240 USAUniv Iowa, Dept Internal Med, Iowa City, IA 52240 USA
机构:
Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, ScotlandWestern Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Cáceres, JF
Kornblihtt, AR
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机构:Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
机构:Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Cáceres, JF
Screaton, GR
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机构:Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Screaton, GR
Krainer, AR
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Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, ScotlandWestern Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
机构:
Univ Iowa, Dept Internal Med, Iowa City, IA 52240 USA
Univ Iowa, Dept Mol Physiol & Biophys, Iowa City, IA 52240 USAUniv Iowa, Dept Internal Med, Iowa City, IA 52240 USA
Boudreau, Ryan L.
Martins, Ines
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Internal Med, Iowa City, IA 52240 USAUniv Iowa, Dept Internal Med, Iowa City, IA 52240 USA
Martins, Ines
Davidson, Beverly L.
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机构:
Univ Iowa, Dept Internal Med, Iowa City, IA 52240 USA
Univ Iowa, Dept Mol Physiol & Biophys, Iowa City, IA 52240 USA
Univ Iowa, Dept Neurol, Iowa City, IA 52240 USAUniv Iowa, Dept Internal Med, Iowa City, IA 52240 USA
机构:
Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, ScotlandWestern Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Cáceres, JF
Kornblihtt, AR
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h-index: 0
机构:Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
机构:Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Cáceres, JF
Screaton, GR
论文数: 0引用数: 0
h-index: 0
机构:Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
Screaton, GR
Krainer, AR
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h-index: 0
机构:
Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, ScotlandWestern Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland