Treatment of invasive fungal infections in cancer patients-Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)

被引：117

作者：

Boehme, Angelika ^{[1
]}

Ruhnke, Markus ^{[2
]}

Buchheidt, Dieter ^{[3
]}

Cornely, Oliver A. ^{[4
,5
]}

Einsele, Herrmann ^{[6
]}

Enzensberger, Ruxandra ^{[7
]}

Hebart, Holger ^{[8
]}

Heinz, Werner ^{[6
]}

Junghanss, Christian ^{[9
]}

Karthaus, Meinolf ^{[10
]}

Kruger, William ^{[11
]}

Krug, Utz ^{[12
]}

Kubin, Thomas ^{[13
]}

Penack, Olaf ^{[14
]}

Reichert, Dietmar ^{[15
]}

Reuter, Stefan ^{[16
]}

Silling, Gerda

Sudhoff, Thomas ^{[17
]}

Ullmann, Andrew J. ^{[18
]}

Maschmeyer, Georg ^{[19
]}

机构：

[1] ONKOLOGIKUM, D-60596 Frankfurt, Germany

[2] Charite, Med Klin Poliklin 2, Hamatol Onkol Abt, D-10117 Berlin, Germany

[3] Univ Klinikum Mannheim GmbH, Med Klin 3, D-68167 Mannheim, Germany

[4] Klinikum Univ Koln, Innere Med Klin, D-50937 Cologne, Germany

[5] Klinikum Univ Koln, Zentrum Klin Studien ZKS 0IKN0706, D-50937 Cologne, Germany

[6] Univ Klinikum Wurzburg, Med Klin & Poliklin 2, D-97080 Wurzburg, Germany

[7] Goethe Univ Frankfurt, Inst Med Mikrobiol, Krankenhaus Hyg, D-60596 Frankfurt, Germany

[8] Klinikum Schwabisch Gmund Stauferklin, Zentrum Innere Med, D-73557 Mutlangen, Germany

[9] Univ Rostock, Klin & Poliklin Innere Med, Abt Hamatol & Onkol, D-18057 Rostock, Germany

[10] St Klinikum Munchen Neuperlach, Abt Hamatol Onkol, D-81737 Munich, Germany

[11] Ernst Moritz Arndt Univ Greifswald, Med Klin C, D-17487 Greifswald, Germany

[12] Med Univ Klin, Med Klin A, D-48149 Munster, Germany

[13] Klinikum Traunstein, D-83278 Traunstein, Germany

[14] Campus Benjamin Franklin, Charite, Klin Hamatol & Onkol, D-12200 Berlin, Germany

[15] Hamatol Onkol Gemeinschaftpraxis Dr Reichert Dr J, D-26655 Westerstede, Germany

[16] Univ Klinikum Dusseldorf, Klin Gastroenterol Hepatol & Infektiol, D-40225 Dusseldorf, Germany

[17] Univ Passau, Med Klin 2, D-94032 Passau, Germany

[18] Johannes Gutenberg Univ Mainz, Med Abt 3, D-55131 Mainz, Germany

[19] Klinikum Ernst Von Bergmann, Med Klin, D-14467 Potsdam, Germany

来源：

ANNALS OF HEMATOLOGY | 2009年 / 88卷 / 02期

关键词：

Cancer; Invasive fungal infections; Antifungals; LIPOSOMAL AMPHOTERICIN-B; CHRONIC DISSEMINATED CANDIDIASIS; MULTICENTER RANDOMIZED-TRIAL; STEM-CELL TRANSPLANTATION; LIPID COMPLEX; NEUTROPENIC PATIENTS; SALVAGE THERAPY; HEPATOSPLENIC CANDIDIASIS; PULMONARY ASPERGILLOSIS; CRYPTOCOCCAL MENINGITIS;

D O I：

10.1007/s00277-008-0622-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Invasive fungal infections are a main cause of morbidity and mortality in cancer patients undergoing intensive chemotherapy regimens. Early antifungal treatment is mandatory to improve survival. Today, a number of effective and better-tolerated but more expensive antifungal agents compared to the former gold standard amphotericin B deoxycholate are available. Clinical decision-making must consider results from numerous studies and published guidelines, as well as licensing status and cost pressure. New developments in antifungal prophylaxis improving survival rates result in a continuous need for actualization. The treatment options for invasive Candida infections include fluconazole, voriconazole, and amphotericin B and its lipid formulations, as well as echinocandins. Voriconazole, amphotericin B, amphotericin B lipid formulations, caspofungin, itraconazole, and posaconazole are available for the treatment of invasive aspergillosis. Additional procedures, such as surgical interventions, immunoregulatory therapy, and granulocyte transfusions, have to be considered. The Infectious Diseases Working Party of the German Society of Hematology and Oncology here presents its 2008 recommendations discussing the dos and do-nots, as well as the problems and possible solutions, of evidence criteria selection.

引用

页码：CP6 / 110

页数：14

共 115 条

[1] FLUCONAZOLE THERAPY FOR CHRONIC DISSEMINATED CANDIDIASIS IN PATIENTS WITH LEUKEMIA AND PRIOR AMPHOTERICIN-B THERAPY [J].