The who, where, and when of IgE in allergic airway disease

被引：160

作者：

Dullaers, Melissa ^{[1
]}

De Bruyne, Ruth ^{[2
]}

Ramadani, Faruk ^{[3
,4
,5
]}

Gould, Hannah J. ^{[3
,4
,5
]}

Gevaert, Philippe ^{[6
]}

Lambrecht, Bart N. ^{[1
]}

机构：

[1] Univ Hosp Ghent, Lab Immunoregulat & Mucosal Immunol, Dept Pulm Med, Ghent, Belgium

[2] Univ Hosp Ghent, Dept Paediat Gastroenterol & Hepatol, Ghent, Belgium

[3] Kings Coll London, Randall Div Cell & Mol Biophys, London, England

[4] Kings Coll London, MRC, London, England

[5] Kings Coll London, Asthma UK Ctr Allerg Mech Asthma, London, England

[6] Univ Ghent, Upper Airways Res Lab, Dept Otorhinolaryngol, Ghent, Belgium

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2012年 / 129卷 / 03期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

IgE; atopic asthma; allergic rhinitis; memory B cells; plasma cells; CLASS SWITCH RECOMBINATION; GERMLINE GENE TRANSCRIPTS; EPSILON-HEAVY-CHAIN; NERVE GROWTH-FACTOR; NASAL B-CELLS; DENDRITIC CELLS; PLASMA-CELLS; PERIPHERAL-BLOOD; SOMATIC HYPERMUTATION; DEPENDENT MECHANISM;

D O I：

10.1016/j.jaci.2011.10.029

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

Allergic asthma and allergic rhinitis/conjunctivitis are characterized by a T(H)2-dominated immune response associated with increased serum IgE levels in response to inhaled allergens. Because IgE is a key player in the induction and maintenance of allergic inflammation, it represents a prime target for therapeutic intervention. However, our understanding of IgE biology remains fragmentary. This article puts together our current knowledge on IgE in allergic airway diseases with a special focus on the identity of IgE-secreting cells ("who''), their location ("where''), and the circumstances in which they are induced ("when''). We further consider the therapeutic implications of the insights gained. (J Allergy Clin Immunol 2012; 129: 635-45.)

引用

页码：635 / 645

页数：11

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