Asthma, COPD and overlap syndrome: a longitudinal study in young European adults

被引：110

作者：

de Marco, Roberto ^{[1
]}

Marcon, Alessandro ^{[1
]}

Rossi, Andrea ^{[2
,3
]}

Anto, Josep M. ^{[4
,5
,6
,7
]}

Cerveri, Isa ^{[8
]}

Gislason, Thorarinn ^{[9
,10
]}

Heinrich, Joachim ^{[11
,12
]}

Janson, Christer ^{[13
]}

Jarvis, Deborah ^{[14
]}

Kuenzli, Nino ^{[15
,16
]}

Leynaert, Benedicte ^{[17
]}

Probst-Hensch, Nicole ^{[15
,16
]}

Svanes, Cecilie ^{[18
,19
]}

Wjst, Matthias ^{[20
,21
]}

Burney, Peter ^{[14
]}

机构：

[1] Univ Verona, Dept Publ Hlth & Community Med, Unit Epidemiol & Med Stat, I-37134 Verona, Italy

[2] Azienda Osped Univ Integrata, Pulm Unit, Verona, Italy

[3] Univ Verona, I-37134 Verona, Italy

[4] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain

[5] Hosp del Mar, Med Res Inst, Barcelona, Spain

[6] Univ Pompeu Fabra, Barcelona, Spain

[7] CIBERESP, Barcelona, Spain

[8] Univ Pavia, San Matteo Hosp Fdn, Ist Ricovero & Cura Carattere Sci, I-27100 Pavia, Italy

[9] Landspitali Univ Hosp, Dept Resp Med & Sleep, Reykjavik, Iceland

[10] Univ Iceland, Fac Med, Reykjavik, Iceland

[11] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, Munich, Germany

[12] Univ Munich, Univ Hosp Munich, Inner City Clin, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany

[13] Univ Uppsala Hosp, Dept Med Sci Resp Med & Allergol, Uppsala, Sweden

[14] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol & Publ Hlth Grp, London, England

[15] Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland

[16] Univ Basel, Basel, Switzerland

[17] Fac Paris Diderot, INSERM, Inserm Epidemiol U1152, Paris, France

[18] Univ Bergen, Ctr Int Hlth, Bergen Resp Res Grp, Bergen, Norway

[19] Haukeland Hosp, Dept Occupat Med, N-5021 Bergen, Norway

[20] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Lung Biol & Dis, Comprehens Pneumol Ctr, Munich, Germany

[21] Tech Univ Munich, Inst Med Stat & Epidemiol, D-80290 Munich, Germany

来源：

EUROPEAN RESPIRATORY JOURNAL | 2015年 / 46卷 / 03期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; PROPORTIONAL VENN-DIAGRAM; LUNG-FUNCTION; UNITED-STATES; CHALLENGE; FEATURES; PREDICT; COHORT;

D O I：

10.1183/09031936.00008615

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

We compared risk factors and clinical characteristics, 9-year lung function change and hospitalisation risk across subjects with the asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS), asthma or COPD alone, or none of these diseases. Participants in the European Community Respiratory Health Survey in 1991-1993 (aged 20-44 years) and 1999-2001 were included. Chronic airflow obstruction was defined as pre-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity<lower limit of normal on both occasions. Based on their history of respiratory symptoms, spirometry and risk factors, subjects were classified as having asthma alone (n=941), COPD alone (n=166), ACOS (n=218) and none of these (n=5659). Subjects with ACOS shared risk factors and clinical characteristics with subjects with asthma alone, but they had an earlier age of asthma onset. FEV1 change in the ACOS group (-25.9 mL.year(-1)) was similar to that in the asthma group (-25.3 mL.year(-1)), and lower (p<0.001) than in the COPD group (-37.3 mL.year(-1)). ACOS was associated with the highest hospitalisation rate. Among young adults aged 20-44 years, ACOS seems to represent a form of severe asthma, characterised by more frequent hospitalisations, and to be the result of early-onset asthma that has progressed to fixed airflow obstruction.

引用

页码：671 / 679

页数：9

共 38 条

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