New promising molecular targets in head and neck squamous cell carcinoma

被引：34

作者：

Bauman, Julie E. ^{[2
]}

Michel, Loren S. ^{[3
,4
]}

Chung, Christine H. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Oncol, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

[2] Univ New Mexico, Ctr Canc, Dept Internal Med, Div Hematol Oncol, Albuquerque, NM 87131 USA

[3] Washington Univ, Sch Med, Dept Internal Med, Div Oncol,Dept Cell Biol & Physiol, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Alvin J Siteman Canc Ctr, St Louis, MO USA

来源：

CURRENT OPINION IN ONCOLOGY | 2012年 / 24卷 / 03期

关键词：

DNA damage repair; EGFR; HNSCC; HPV; hypoxia; MET; NOTCH; 1; PIK3CA; TP53; MESENCHYMAL-LIKE SUBPOPULATIONS; FACTOR RECEPTOR GENE; HUMAN-PAPILLOMAVIRUS; C-MET; TUMOR-SUPPRESSOR; HYPOXIC MODIFICATION; ACQUIRED-RESISTANCE; THERAPEUTIC TARGET; CANCER INCIDENCE; PLUS CETUXIMAB;

D O I：

10.1097/CCO.0b013e3283517920

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Purpose of review Despite advances in multimodality therapy, the overall 5-year survival rate is 40-50% in patients with head and neck squamous cell carcinoma (HNSCC) and current multimodality approaches impart significant toxicities. This review highlights promising targets with the potential to improve clinical outcomes in HNSCC. Recent findings In addition to mutagenic exposure to tobacco and alcohol as risk factors, recent studies have shown that human papillomavirus is one of the main causes of HNSCC and as such is being investigated as a therapeutic target. Furthermore, recent data generated from whole exome sequencing of HNSCC, new insights into the biology of DNA damage repair, and increased understanding of tumor hypoxia responses are pointing to new therapeutic possibilities for treating HNSCC. Summary HNSCC is a heterogeneous disease. Improved treatment will require a rapid translation of basic science research, and the simultaneous development of novel therapeutics and corresponding biomarkers to guide their application.

引用

页码：235 / 242

页数：8

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