Mechanisms of iron-sulfur cluster assembly: the SUF machinery

被引：89

作者：

Fontecave, M

de Choudens, SO

Py, B

Barras, F

机构：

[1] Univ Grenoble 1, CEA Grenoble, UMR 5047,DRDC CB, Ctr Redox Biol,Lab Chim & Biochim,CNRS,CEA, F-38054 Grenoble, France

[2] IBSM, Chim Bacterienne Lab, CNRS, UPR 9043, F-13402 Marseille, France

来源：

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY | 2005年 / 10卷 / 07期

关键词：

iron-sulfur cluster; biosynthesis; cluster assembly; cysteine desulfurase; scaffold protein; oxidative stress;

D O I：

10.1007/s00775-005-0025-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biosynthesis of iron-sulfur clusters is a cellular process which depends on complex protein machineries. Escherichia coli contains two such biosynthetic systems, ISC and SUF. In this review article we specifically make a presentation of the various Suf proteins and discuss the molecular mechanisms by which these proteins work together to assemble Fe and S atoms within a scaffold and to transfer the resulting cluster to target proteins.

引用

页码：713 / 721

页数：9

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