Interventional therapy combined with immune checkpoint inhibitors: Emerging opportunities for cancer treatment in the era of immunotherapy

被引：58

作者：

Chang, Xiaofeng ^{[1
,2
,3
]}

Lu, Xiaofeng ^{[3
]}

Guo, Jinhe ^{[1
]}

Teng, Gao-Jun ^{[1
,2
]}

机构：

[1] Southeast Univ, Ctr Intervent Radiol & Vasc Surg, Dept Radiol, Zhongda Hosp,Med Sch, 87 Dingjiaqiao, Nanjing 210009, Jiangsu, Peoples R China

[2] Collaborat Innovat Ctr Suzhou Nanosci & Technol, Suzhou Key Lab Biomat & Technol, Suzhou, Peoples R China

[3] Nanjing Univ, Sch Med, Nanjing Drum Tower Hosp, Nanjing, Jiangsu, Peoples R China

来源：

CANCER TREATMENT REVIEWS | 2019年 / 74卷

基金：

中国国家自然科学基金;

关键词：

Interventional oncology; Immune checkpoint inhibitor; Immunotherapy; Synergistic effect; LONG-TERM SAFETY; METASTATIC UROTHELIAL CARCINOMA; CISPLATIN-INELIGIBLE PATIENTS; NIVOLUMAB PLUS IPILIMUMAB; RESISTANT PROSTATE-CANCER; SQUAMOUS-CELL CARCINOMA; REGULATORY T-CELL; OPEN-LABEL; HEPATOCELLULAR-CARCINOMA; RADIOFREQUENCY ABLATION;

D O I：

10.1016/j.ctrv.2018.08.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Immune checkpoint inhibitors-based immunotherapy offers a new effective modality in the treatment of advanced malignancies. Considering the remarkable efficacy of immune checkpoint inhibitors in clinical trials, the FDA has approved a variety of immune checkpoint inhibitors for the treatment of advanced tumors. However, only limited patients with certain cancers can benefit from monotherapy of immune checkpoint inhibitors. Interventional therapy for cancer can not only destroy the primary tumors, but also regulate the immune system through different mechanisms, which provides a potential possibility for the combination of immune checkpoint inhibitors and Interventional modalities in cancer treatment. This article reviews the possible synergistic mechanisms of interventional therapy combined with immune checkpoint inhibitors and summarizes the research progress of the combined therapy in cancer treatment.

引用

页码：49 / 60

页数：12

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