1,25-dihydroxyvitamin D-3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis

被引：569

作者：

Cantorna, MT ^{[1
]}

Hayes, CE ^{[1
]}

DeLuca, HF ^{[1
]}

机构：

[1] UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 15期

关键词：

vitamin D; vitamin D deficiency; myelin basic protein; autoimmunity;

D O I：

10.1073/pnas.93.15.7861

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP), EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D-3 [1,25-(OH)(2)D-3]. 1,25-(OH)(2)D-3 could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)(2)D-3 resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)(2)D-3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)(2)D-3 or its analogs are potentially important for treatment of MS.

引用

页码：7861 / 7864

页数：4

共 20 条

[1]

SPECIFIC HIGH-AFFINITY RECEPTORS FOR 1,25-DIHYDROXYVITAMIN-D3 IN HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS - PRESENCE IN MONOCYTES AND INDUCTION IN LYMPHOCYTES-T FOLLOWING ACTIVATION [J].