Hydroxyurea-induced hypogonadism

被引：1

作者：

Beeson, M

Antwi, EK

Vesely, DL

机构：

[1] James A Haley Vet Hosp, Dept Med, Tampa, FL 33612 USA

[2] James A Haley Vet Hosp, Dept Physiol, Tampa, FL 33612 USA

[3] James A Haley Vet Hosp, Dept Biophys, Tampa, FL 33612 USA

[4] Univ S Florida, Hlth Sci Ctr, Tampa, FL 33612 USA

来源：

ENDOCRINOLOGIST | 1999年 / 9卷 / 05期

关键词：

D O I：

10.1097/00019616-199909000-00010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hydroxyurea is commonly used for the treatment of polycythemia vera, essential thrombocytopenia, beta thalassemia, and chronic myelogenous leukemia. We report a case of hydroxyurea-associated testicular atrophy with low circulating testosterone and high follicle stimulating hormone levels. Although hydroxyurea-induced hypogonadism has not been reported in humans previously, this case illustrates that hydroxyureas cause testicular atrophy in humans similar to that found previously with hydroxyurea in animals.

引用

页码：389 / 390

页数：2

共 6 条

[1]

CAPIZZI RL, 1994, INTERNAL MED, P720

[2]

DAHI KD, 1992, J ANDROL, V13, P11

[3] CELL-CYCLE ANALYSIS OF SODIUM-BUTYRATE AND HYDROXYUREA, INDUCERS OF ECTOPIC HORMONE PRODUCTION IN HELA-CELLS [J].