Imidazole release from the antitumor-active ruthenium complex imidazolium trans-tetrachlorobis (imidazole) ruthenate(III) by biologically occurring nucleophiles

被引：43

作者：

Hartmann, M ^{[1
]}

Lipponer, KG ^{[1
]}

Keppler, BK ^{[1
]}

机构：

[1] UNIV VIENNA,INST ANORGAN CHEM,A-1090 VIENNA,AUSTRIA

来源：

INORGANICA CHIMICA ACTA | 1998年 / 267卷 / 01期

关键词：

ruthenium complexes; tumour-inhibiting complexes; glutathione complexes; cisplatin; ligand exchanges;

D O I：

10.1016/S0020-1693(97)05556-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The antitumor-active complex HIm[trans-(RuCl4)-Cl-III(im)(2)], imidazolium trans-tetrachlorobis(imidazole)ruthenate(III), completely changes its ligand configuration within 1 h in water in the presence of L-histidine and L-glutathione. The observed release of the trans-standing imidazole ligands at 37 degrees C that occurs in addition to chloride substitution reactions has to be taken into consideration for further investigations into the mode of action of this new antitumor drug. (C) 1998 Elsevier Science S.A.

引用

页码：137 / 141

页数：5

共 30 条

[1] SYNTHESIS OF THE TETRACHLOROBIS(5-NITROIMIDAZOLE)RUTHENIUM(III) ANION AND SOLUTION CHEMISTRY IN WATER AND METHANOL [J].