NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants

被引：715

作者：

Fu, Zheng Qing ^{[1
]}

Yan, Shunping ^{[1
]}

Saleh, Abdelaty ^{[1
]}

Wang, Wei ^{[1
]}

Ruble, James ^{[2
]}

Oka, Nodoka ^{[3
]}

Mohan, Rajinikanth ^{[1
]}

Spoel, Steven H. ^{[4
]}

Tada, Yasuomi ^{[5
]}

Zheng, Ning ^{[2
]}

Dong, Xinnian ^{[1
]}

机构：

[1] Duke Univ, Howard Hughes Med Inst, Gordon & Betty Moore Fdn, Dept Biol, Durham, NC 27708 USA

[2] Univ Washington, Howard Hughes Med Inst, Dept Pharmacol, Seattle, WA 98195 USA

[3] Kagawa Univ, Fac Agr, Miki, Kagawa 7610795, Japan

[4] Univ Edinburgh, Inst Mol Plant Sci, Edinburgh EH9 3JR, Midlothian, Scotland

[5] Kagawa Univ, Life Sci Res Ctr, Inst Res Promot, Miki, Kagawa 7610795, Japan

来源：

NATURE | 2012年 / 486卷 / 7402期

基金：

美国国家科学基金会;

关键词：

SYSTEMIC ACQUIRED-RESISTANCE; CELL-DEATH; PSEUDOMONAS-SYRINGAE; DEFENSE GENES; ARABIDOPSIS; TOBACCO; INDUCTION; PERCEPTION; INTERACTS; REVEALS;

D O I：

10.1038/nature11162

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Salicylic acid (SA) is a plant immune signal produced after pathogen challenge to induce systemic acquired resistance. It is the only major plant hormone for which the receptor has not been firmly identified. Systemic acquired resistance in Arabidopsis requires the transcription cofactor nonexpresser of PR genes 1 (NPR1), the degradation of which acts as a molecular switch. Here we show that the NPR1 paralogues NPR3 and NPR4 are SA receptors that bind SA with different affinities. NPR3 and NPR4 function as adaptors of the Cullin 3 ubiquitin E3 ligase to mediate NPR1 degradation in an SA-regulated manner. Accordingly, the Arabidopsis npr3 npr4 double mutant accumulates higher levels of NPR1, and is insensitive to induction of systemic acquired resistance. Moreover, this mutant is defective in pathogen effector-triggered programmed cell death and immunity. Our study reveals the mechanism of SA perception in determining cell death and survival in response to pathogen challenge.

引用

页码：228 / +

页数：6

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