Nucleic acid analog peptide (NAAP) .2. Syntheses and properties of novel DNA analog peptides containing nucleobase linked beta-aminoalanine.

被引：22

作者：

Fujii, M ^{[1
]}

Yoshida, K ^{[1
]}

Hidaka, J ^{[1
]}

Ohtsu, T ^{[1
]}

机构：

[1] KINKI UNIV,FAC BIOL SCI & ENGN,DEPT GEN EDUC,WAKAYAMA 64964,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(97)00073-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As substitutes for antisense and tripler oligonucleotides, oligopeptides containing N-beta-(thymin-1-ylacetyl) beta-aminoalanine and N-beta-(cytosin-1-ylacetyl) beta-aminoalanine moieties were synthesized on solid support by using standard Boc-chemistry. The obtained peptide containing ten thymine bases was shown to form a hybrid duplex with a complementary oligo DNA, dA(10), with a melting temperature (Tm) of 36.5 degrees C at pH 7.0. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：637 / 640

页数：4

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