In vivo evidence for dendritic cell lysis by NK cells Hints on improving cancer vaccines by targeting NK cell activation

被引：5

作者：

Ferlazzo, Guido ^{[1
]}

机构：

[1] Univ Messina, Lab Immunol & Biotherapy, Dept Human Pathol, Messina, Italy

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 09期

关键词：

Cancer vaccines; cytotoxic T lymphocytes; dendritic cells; natural killer cells; lymph nodes; perforin; NATURAL-KILLER-CELLS; INFECTION; TISSUES; T(H)1;

D O I：

10.4161/onci.21682

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

By using an experimental model of anticancer vaccination, we have recently lent support to the assumption, so far only sustained by in vitro data, that natural killer cells can restrain less immunogenic, allegedly tolerogenic, dendritic cells (DCs). This in vivo selection of immunogenic DCs appears to depend on perforin and to be associated with a more protective tumor-specific T lymphocyte response.

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收藏

页码：1635 / 1636

页数：2

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