Isolation of streptonigrin and its novel derivative from Micromonospora as inducing agents of p53-dependent cell apoptosis

被引:29
作者
Wang, HS
Yeo, SL
Xu, J
Xu, XL
He, H
Ronca, F
Ting, AE
Wang, Y
Yu, VC
Sim, MM
机构
[1] Med & Combinatorial Chem Lab, Lead Discovery Grp, Microbial Collect & Screening Lab, Screening Novel Inhibitors Grp, Singapore 117609, Singapore
[2] Apoptosis Signalling Lab, Inst Mol & Cell Biol, Singapore 117609, Singapore
来源
JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 05期
关键词
D O I
10.1021/np0104572
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Streptonigrin (1) and its novel natural derivative 7-(1-methyl-2-oxopropyl)streptonigrin (2) were isolated from an actinomycete strain, Micromonospora sp. IM 2670. The inductions for 1 and 2 are more potent in the human neuroblastoma SH-SY5Y cells that contain wild-type p53 than in SH-SY5Y-5.6 cells that overexpress a dominant negative mutant of p53, thus suggesting that they induce apoptosis through a p53-dependent pathway.
引用
收藏
页码:721 / 724
页数:4
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