Bistable oscillations arising from synaptic depression

Synaptic depression is a common form of short-term plasticity in the central and peripheral nervous systems. We show that in a network of two reciprocally connected neurons a single depressing synapse can produce two distinct oscillatory regimes. These distinct periodic behaviors can be studied by varying the maximal conductance, (g) over bar (inh), of the depressing synapse. For small (g) over bar (inh), the network has a short-period solution controlled by intrinsic cellular properties. For large (g) over bar (inh), the solution has a much longer period and is controlled by properties of the synapse. We show that in an intermediate range of (g) over bar (inh) values both stable periodic solutions exist simultaneously. Thus the network can switch oscillatory modes either by changing (g) over bar (inh) or, for fixed (g) over bar (inh), by changing initial conditions.