Interplay between TRP channels and the cytoskeleton in health and disease

被引：48

作者：

Clark, Kristopher ^{[1
,2
]}

Middelbeek, Jeroen ^{[1
]}

van Leeuwen, Frank N. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Nijmegen Ctr Mol Life Sci, Lab Pediat Oncol, NL-6500 HB Nijmegen, Netherlands

[2] Univ Dundee, MRC, Prot Phosphorylat Unit, James Black Ctr, Dundee DD1 5EH, Scotland

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2008年 / 87卷 / 8-9期

关键词：

TRP; channels; actin; tubulin; myosin; cytoskeleton; mechanotransduction;

D O I：

10.1016/j.ejcb.2008.01.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transient receptor potential (TRP) channels are a family of cation channels that play a key role in ion homeostasis and cell volume regulation. In addition, TRP channels are considered universal integrators of sensory information required for taste, vision, hearing, touch, temperature, and the detection of mechanical force. Seminal investigations exploring the molecular mechanisms of phototransduction in Drosophila have demonstrated that TRP channels operate within macromolecular complexes closely associated with the cytoskeleton. More recent evidence shows that mammalian TRP channels similarly connect to the cytoskeleton to affect cytoskeletal organization and cell adhesion via ion-transport-dependent and independent mechanisms. In this review, we discuss new insights into the interplay between TRP channels and the cytoskeleton and provide recent examples Of Such Interactions in different physiological systems. (C) 2008 Elsevier GmbH. All rights reserved.

引用

页码：631 / 640

页数：10

共 84 条

[21] Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na+/K+-ATPase [J].