Synthesis and biological activities of phenylahistin derivatives

被引：65

作者：

Kanoh, K ^{[1
]}

Kohno, S ^{[1
]}

Katada, J ^{[1
]}

Takahashi, J ^{[1
]}

Uno, I ^{[1
]}

Hayashi, Y ^{[1
]}

机构：

[1] Nippon Steel Corp Ltd, Life Sci Res Ctr, Adv Technol Res Labs, Kawasaki, Kanagawa 2110035, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1999年 / 7卷 / 07期

关键词：

amino acids and derivatives; antitumor compounds; X-ray crystal structure; natural products;

D O I：

10.1016/S0968-0896(99)00059-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

X-ray crystallographic analysis was performed and several phenylahistin derivatives were synthesized to elucidate the structural components necessary for the anti-microtubule activity of phenylahistin. We primarily focused on the unique isoprenylated dehydrohistidine structure. Our results showed that a uniplanar pseudo-three-ring structure formed by the hydrogen bonding of diketopiperazine and imidazole rings is important for the anti-microtubule activity of phenylahistin. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1451 / 1457

页数：7

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