An Information-Theoretic Analysis of Genetics, Gender and Age in Cancer Patients

被引：16

作者：

Atwal, Gurinder Singh ^{[1
]}

Rabadan, Raul ^{[1
]}

Lozano, Guillermina ^{[3
]}

Strong, Louise C. ^{[3
]}

Ruijs, Marielle W. G. ^{[4
,6
]}

Schmidt, Marjanka K. ^{[5
]}

van't Veer, Laura J. ^{[4
]}

Nevanlinna, Heli ^{[7
]}

Tommiska, Johanna ^{[7
]}

Aittomaki, Kristiina ^{[8
]}

Bougeard, Gaelle ^{[9
]}

Frebourg, Thierry ^{[9
]}

Levine, Arnold J. ^{[1
,2
]}

Bond, Gareth L. ^{[1
]}

机构：

[1] Inst Advanced Study, Princeton, NJ USA

[2] Canc Inst New Jersey, New Brunswick, NJ USA

[3] MD Anderson Canc Ctr, Univ Texas, Houston, TX USA

[4] Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands

[5] Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands

[6] Vrije Univ Amsterdam, Med Ctr, Dept Clin Genet & Human Genet, Amsterdam, Netherlands

[7] Helsinki Univ, Central Hosp, Dept Obstet & Gynaecol, Helsinki, Finland

[8] Helsinki Univ, Central Hosp, Dept Clin Genet, Helsinki, Finland

[9] Rouen Univ Hosp, Inst Biomed Res, Dept Genet, Inserm U614, Rouen, France

来源：

PLOS ONE | 2008年 / 3卷 / 04期

关键词：

D O I：

10.1371/journal.pone.0001951

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Germline genetics, gender and hormonal-signaling pathways are all well described modifiers of cancer risk and progression. Although an improved understanding of how germline genetic variants interact with other cancer risk factors may allow better prevention and treatment of human cancer, measuring and quantifying these interactions is challenging. In other areas of research, Information Theory has been used to quantitatively describe similar multivariate interactions. We implemented a novel information-theoretic analysis to measure the joint effect of a high frequency germline genetic variant of the p53 tumor suppressor pathway (MDM2 SNP309 T/G) and gender on clinical cancer phenotypes. This analysis quantitatively describes synergistic interactions among gender, the MDM2 SNP309 locus, and the age of onset of tumorigenesis in p53 mutation carriers. These results offer a molecular and genetic basis for the observed sexual dimorphism of cancer risk in p53 mutation carriers and a model is proposed that suggests a novel cancer prevention strategy for p53 mutation carriers.

引用

页数：7

共 37 条

[1] The MDM2 promoter polymorphism SNP309T→G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck [J].