Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: Stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase

被引:65
作者
VanVeldhoven, PP [1 ]
Croes, K [1 ]
Asselberghs, S [1 ]
Herdewijn, P [1 ]
Mannaerts, GP [1 ]
机构
[1] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM
关键词
bile acid; isoprenoid; pristanic acid; phytanic acid; racemase; Zellweger syndrome;
D O I
10.1016/0014-5793(96)00508-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase, purified from rat liver, both catalyse the desaturation of 2-methyl-branched acyl-CoAs. Upon incubation with the pure isomers of 2-methylpentadecanoyl-CoA, both enzymes acted only on the S-isomer, The R-isomer inhibited trihydroxycoprostanoyl-CoA oxidase but did not affect pristanoyl-CoA oxidase, The activity of both enzymes was suppressed by 3-methylheptadecanoyl-CoA. Valproyl-CoA and 2-ethylhexanoyl-CoA, however, did not influence the oxidases, Although only one isomer of 25R,S-trihydroxycoprostanoyl-CoA was desaturated by trihydroxycoprostanoyl-CoA oxidase, isolated peroxisomes were able to act on both isomers, suggesting the presence of a racemase in these organelles, Given the opposite stereoselectivity of the 26-cholesterol hydroxylase and of the oxidase, the racemase is essential for bile acid formation.
引用
收藏
页码:80 / 84
页数:5
相关论文
共 48 条
[1]   OCCURRENCE OF DIASTEREOMERS OF PHYTANIC AND PRISTANIC ACIDS AND THEIR DETERMINATION BY GAS-LIQUID CHROMATOGRAPHY [J].
ACKMAN, RG ;
HANSEN, RP .
LIPIDS, 1967, 2 (05) :357-+
[2]  
BATTA AK, 1979, J LIPID RES, V20, P935
[3]  
BATTA AK, 1983, J LIPID RES, V24, P94
[4]   ON THE METABOLISM OF 3-ALPHA, 7-ALPHA, 12-ALPHA-TRIHYDROXYCOPROSTANIC ACID IN THE RAT [J].
BRIDGWATER, RJ ;
LINDSTEDT, S .
ACTA CHEMICA SCANDINAVICA, 1957, 11 (03) :409-413
[5]  
BROSS P, 1990, J BIOL CHEM, V265, P7116
[6]  
CASTEELS M, 1988, J BIOL CHEM, V263, P4654
[7]   IDENTIFICATION OF THE CATALYTIC BASE IN LONG-CHAIN ACYL-COA DEHYDROGENASE [J].
DJORDJEVIC, S ;
DONG, Y ;
PASCHKE, R ;
FRERMAN, FE ;
STRAUSS, AW ;
KIM, JJP .
BIOCHEMISTRY, 1994, 33 (14) :4258-4264
[8]   IDENTIFICATION OF 3-ALPHA,7-ALPHA,12-ALPHA-TRIHYDROXY-5-BETA-CHOLEST-24-ENOIC ACID AS AN INTERMEDIATE IN THE PEROXISOMAL CONVERSION OF 3-ALPHA,7-ALPHA,12-ALPHA-TRIHYDROXY-5-BETA-CHOLESTANOIC ACID TO CHOLIC-ACID [J].
FARRANTS, AKO ;
BJORKHEM, I ;
PEDERSEN, JI .
BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 1002 (02) :198-202
[9]  
GHISLA S, 1992, PROG CLIN BIOL RES, V375, P127
[10]  
GUSTAFSSON J, 1978, J BIOL CHEM, V253, P199