New syntheses of orelline and analogues via metalation and cross-coupling reactions

被引：20

作者：

Mongin, F ^{[1
]}

Trécourt, F ^{[1
]}

Mongin, O ^{[1
]}

Quéguiner, G ^{[1
]}

机构：

[1] IRCOF, UMR 6014, Lab Chim Organ Fine & Heterocycl, F-76131 Mont St Aignan, France

来源：

TETRAHEDRON | 2002年 / 58卷 / 02期

关键词：

alkaloids; pyridine; metalation; coupling reactions;

D O I：

10.1016/S0040-4020(01)01142-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New total syntheses of orelline and some analogues are reported. The methodology involves metalation of 3-alkoxy-2-iodopyridines to afford 3,4-dialkoxy-2-iodopyridines, on which cross-coupling reactions are performed to reach the 2,2'-bipyridine skeleton of the alkaloid. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：309 / 314

页数：6

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