Association of MicroRNA-146a with Autoimmune Diseases

被引：88

作者：

Xu, Wang-Dong ^{[1
]}

Lu, Man-Man ^{[1
]}

Pan, Hai-Feng ^{[1
]}

Ye, Dong-Qing ^{[1
]}

机构：

[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Anhui, Peoples R China

来源：

INFLAMMATION | 2012年 / 35卷 / 04期

基金：

中国国家自然科学基金;

关键词：

MiR-146a; autoimmunity; autoimmune diseases; FAS-ASSOCIATED FACTOR-1; NF-KAPPA-B; PRIMARY SJOGRENS-SYNDROME; TOLL-LIKE RECEPTORS; RHEUMATOID-ARTHRITIS; T-CELLS; MIR-146A EXPRESSION; HUMAN LUPUS; TOLL-LIKE-RECEPTOR-7; ACTIVATION;

D O I：

10.1007/s10753-012-9467-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) are a group of approximately 20-22-nucleotide-long non-coding RNAs that repress target gene expression through mRNA degradation and translation inhibition. MiRNA (miR)-146a, located in the second exon of the LOC285628 gene on human chromosome 5, is a negative regulator in immune and inflammatory responses. Studies have indicated that miR-146a is associated with the pathogenesis of several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and Sjogren's syndrome. In this review, emphasis will be laid on the recent progress in the functional roles of miR-146a in these autoimmune diseases.

引用

页码：1525 / 1529

页数：5

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