Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases

被引：411

作者：

Musti, AM ^{[1
]}

Treier, M ^{[1
]}

Bohmann, D ^{[1
]}

机构：

[1] EUROPEAN MOL BIOL LAB,D-69117 HEIDELBERG,GERMANY

来源：

SCIENCE | 1997年 / 275卷 / 5298期

关键词：

D O I：

10.1126/science.275.5298.400

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a number of inducers that act through mitogen-activated protein kinase (MAPK) signal transduction pathways. The activation of c-Jun after phosphorylation by MAPK is accompanied by a reduction in c-Jun ubiquitination and consequent stabilization of the protein. These results illustrate the relevance of regulated protein degradation in the signal-dependent central oi gene expression.

引用

页码：400 / 402

页数：3

共 17 条

[1] HA-RAS AUGMENTS C-JUN ACTIVITY AND STIMULATES PHOSPHORYLATION OF ITS ACTIVATION DOMAIN
BINETRUY, B
SMEAL, T
KARIN, M
[J]. NATURE, 1991, 351 (6322) : 122 - 127
[2] THE SMALL GTP-BINDING PROTEINS RAC1 AND CDC42 REGULATE THE ACTIVITY OF THE JNK/SAPK SIGNALING PATHWAY
COSO, OA
CHIARIELLO, M
YU, JC
TERAMOTO, H
CRESPO, P
XU, NG
MIKI, T
GUTKIND, JS
[J]. CELL, 1995, 81 (07) : 1137 - 1146
[3] JNK1 - A PROTEIN-KINASE STIMULATED BY UV-LIGHT AND HA-RAS THAT BINDS AND PHOSPHORYLATES THE C-JUN ACTIVATION DOMAIN
DERIJARD, B
HIBI, M
WU, IH
BARRETT, T
SU, B
DENG, TL
KARIN, M
DAVIS, RJ
[J]. CELL, 1994, 76 (06) : 1025 - 1037
[4] GLOTZER M, 1991, NATURE, V349, P132, DOI 10.1038/349132a0
[5] NEW TECHNIQUE FOR ASSAY OF INFECTIVITY OF HUMAN ADENOVIRUS 5 DNA
GRAHAM, FL
VANDEREB, AJ
[J]. VIROLOGY, 1973, 52 (02) : 456 - 467
[6] UBIQUITIN, PROTEASOMES, AND THE REGULATION OF INTRACELLULAR PROTEIN-DEGRADATION
HOCHSTRASSER, M
[J]. CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (02) : 215 - 223
[7] Isaksson A., 1996, BIOCHIM BIOPHYS ACTA, V1288, P21
[8] SELECTIVE PROTEIN-DEGRADATION - A JOURNEYS END WITHIN THE PROTEASOME
JENTSCH, S
SCHLENKER, S
[J]. CELL, 1995, 82 (06) : 881 - 884
[9] THE MOS/MAP KINASE PATHWAY STABILIZES C-FOS BY PHOSPHORYLATION AND AUGMENTS ITS TRANSFORMING ACTIVITY IN NIH 3T3 CELLS
OKAZAKI, K
SAGATA, N
[J]. EMBO JOURNAL, 1995, 14 (20) : 5048 - 5059
[10] THE UBIQUITIN-PROTEASOME PATHWAY IS REQUIRED FOR PROCESSING THE NF-KAPPA-B1 PRECURSOR PROTEIN AND THE ACTIVATION OF NF-KAPPA-B
PALOMBELLA, VJ
RANDO, OJ
GOLDBERG, AL
MANIATIS, T
[J]. CELL, 1994, 78 (05) : 773 - 785

← 1 2 →