Control of inflammation by integration of environmental cues by regulatory T cells

被引：150

作者：

Chaudhry, Ashutosh

Rudensky, Alexander Y.

机构：

[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10021 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 03期

关键词：

TRANSCRIPTION FACTOR GATA-3; IFN-GAMMA PRODUCTION; INTERLEUKIN; 22; FACTOR FOXP3; TGF-BETA; DIFFERENTIATION; CD4; POPULATION; EXPRESSION; DISTINCT;

D O I：

10.1172/JCI57175

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Tregs have been implicated in control of homeostasis in the immune system and beyond. These cells restrain inflammatory responses to self antigens, commensal microorganisms, allergens, and pathogens and adapt their homeostatic and functional capabilities to a particular environment. In this review, we discuss a general model of integration of environmental cues by Tregs in which specialized Treg homeostatic, migratory, and suppression programs are established in dynamically changing inflammatory environments by maintaining an optimal threshold of activation of transcription factors involved in regulation of the corresponding type of effector immune responses.

引用

收藏

页码：939 / 944

页数：6

相关论文

共 56 条

[1] The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation [J].

Chang, Hua-Chen ;

Sehra, Sarita ;

Goswami, Ritobrata ;

Yao, Weiguo ;

Yu, Qing ;

Stritesky, Gretta L. ;

Jabeen, Rukhsana ;

McKinley, Carl ;

Ahyi, Ayele-Nati ;

Han, Ling ;

Nguyen, Evelyn T. ;

Robertson, Michael J. ;

Perumal, Narayanan B. ;

Tepper, Robert S. ;

Nutt, Stephen L. ;

Kaplan, Mark H. .

NATURE IMMUNOLOGY, 2010, 11 (06) :527-U98

[2] Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation [J].

Chaudhry, Ashutosh ;

Samstein, Robert M. ;

Treuting, Piper ;

Liang, Yuqiong ;

Pils, Marina C. ;

Heinrich, Jan-Michael ;

Jack, Robert S. ;

Wunderlich, F. Thomas ;

Bruening, Jens C. ;

Mueller, Werner ;

Rudensky, Alexander Y. .

IMMUNITY, 2011, 34 (04) :566-578

[3] CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner [J].

Chaudhry, Ashutosh ;

Rudra, Dipayan ;

Treuting, Piper ;

Samstein, Robert M. ;

Liang, Yuqiong ;

Kas, Arnold ;

Rudensky, Alexander Y. .

SCIENCE, 2009, 326 (5955) :986-991

[4] Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions [J].

Chung, Yeonseok ;

Tanaka, Shinya ;

Chu, Fuliang ;

Nurieva, Roza I. ;

Martinez, Gustavo J. ;

Rawal, Seema ;

Wang, Yi-Hong ;

Lim, Hoyong ;

Reynolds, Joseph M. ;

Zhou, Xiao-hui ;

Fan, Hui-min ;

Liu, Zhong-ming ;

Neelapu, Sattva S. ;

Dong, Chen .

NATURE MEDICINE, 2011, 17 (08) :983-U102

[5] PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells [J].

Cipolletta, Daniela ;

Feuerer, Markus ;

Li, Amy ;

Kamei, Nozomu ;

Lee, Jongsoon ;

Shoelson, Steven E. ;

Benoist, Christophe ;

Mathis, Diane .

NATURE, 2012, 486 (7404) :549-U151

[6] The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells [J].

Cretney, Erika ;

Xin, Annie ;

Shi, Wei ;

Minnich, Martina ;

Masson, Frederick ;

Miasari, Maria ;

Belz, Gabrielle T. ;

Smyth, Gordon K. ;

Busslinger, Meinrad ;

Nutt, Stephen L. ;

Kallies, Axel .

NATURE IMMUNOLOGY, 2011, 12 (04) :304-U53

[7] Follicular Helper CD4 T Cells (TFH) [J].

Crotty, Shane .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29, 2011, 29 :621-663

[8] Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells [J].

Duhen, Thomas ;

Geiger, Rebekka ;

Jarrossay, David ;

Lanzavecchia, Antonio ;

Sallusto, Federica .

NATURE IMMUNOLOGY, 2009, 10 (08) :857-U72

[9] Regulatory T cells in stem cell transplantation: strategies and first clinical experiences [J].

Edinger, Matthias ;

Hoffmann, Petra .

CURRENT OPINION IN IMMUNOLOGY, 2011, 23 (05) :679-684

[10] Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming [J].

El Chartouni, Carol ;

Schwarzfischer, Lucia ;

Rehli, Michael .

IMMUNOBIOLOGY, 2010, 215 (9-10) :821-825

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