A mild and efficient synthesis of oxindoles: Progress towards the synthesis of welwitindolinone a isonitrile

被引：71

作者：

Ready, JM ^{[1
]}

Reisman, SE ^{[1
]}

Hirata, M ^{[1
]}

Weiss, MM ^{[1
]}

Tamaki, K ^{[1
]}

Ovaska, TV ^{[1
]}

Wood, JL ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, Sterling Chem Lab, New Haven, CT 06520 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 10期

关键词：

alkaloids; natural products; samarium; total synthesis;

D O I：

10.1002/anie.200353282

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The complete carbon skeleton of welwitindolinone A isonitrile has been prepared by using a [2+2] cycloaddition to establish the bicyclo[4.2.0]octane core and a Sml2-mediated intramolecular reductive cyclization between an enone and an aryl isocyanate to stereoselectively install the spiro-oxindole (see scheme; DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene).

引用

页码：1270 / 1272

页数：3

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