Genetic diversity of human metapneumovirus over 4 consecutive years in Australia

被引：69

作者：

Mackay, Ian M. ^{[1
]}

Bialasiewicz, Seweryn ^{[1
]}

Jacob, Kevin C. ^{[1
]}

McQueen, Emily ^{[1
]}

Arden, Katherine E. ^{[1
]}

Nissen, Michael D. ^{[1
]}

Sloots, Theo P. ^{[1
]}

机构：

[1] Univ Queensland, Clin & Med Virol Ctr, St Lucia, Qld 4067, Australia

来源：

JOURNAL OF INFECTIOUS DISEASES | 2006年 / 193卷 / 12期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1086/504260

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The molecular epidemiologic profile of human metapneumovirus (hMPV) infection has likely been skewed toward certain genetic subtypes because of assay-design issues, and no comprehensive studies have been conducted to date. Here, reverse-transcription polymerase chain reaction was used to screen 10,319 specimens from patients presenting to hospitals with suspected respiratory tract infections during 2001 - 2004. After analysis of 727 Australian hMPV strains, 640 were assigned to 1 of 4 previously described subtypes. hMPV was the most common pathogen detected, and subtype B1 was the most common lineage. Concurrent, annual circulation of all 4 hMPV subtypes in our study population was common, with a single, usually different hMPV subtype predominating in each year.

引用

页码：1630 / 1633

页数：4

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