How does the immune response get started?

被引：17

作者：

Cohn, Melvin ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Conceptual Immunol Group, La Jolla, CA 92037 USA

来源：

CELLULAR IMMUNOLOGY | 2009年 / 254卷 / 02期

关键词：

Self-nonself discrimination; Primer effector T-helper; Costimulation; Activation of T-helpers; SELF-NONSELF DISCRIMINATION; H TH GENESIS; COMPUTERIZED MODEL; SYSTEM; CELLS; LEVEL;

D O I：

10.1016/j.cellimm.2008.10.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

An effective adaptive immune response requires the prior induction of the regulatory effector T-helper (eTh). There are two competing models of how this cell is induced to effectors. Under the Associative Recognition of Antigen (ARA) or "two signal" model, the T-helper requires eTh in order to be induced to eTh, an "autocatalytic" process. Under the "costimulation" model eTh are induced by an antigen-unspecific signal derived from an "activated" APC. Under the ARA model the problem of the origin of the primer eTh is posed. A nonself antigen-independent pathway to eTh is proposed as well as an experiment to reveal its existence. In the costimulation framework no primer eTh need be postulated but it lacks a mechanism that, in the absence of ARA, accounts for the self-nonself discrimination and the determination of effector class. (c) 2008 Elsevier Inc. All fights reserved

引用

页码：91 / 93

页数：3

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