Selective optimization of side activities: Another way for drug discovery

被引：151

作者：

Wermuth, CG ^{[1
]}

机构：

[1] Prestwick Chem Inc, F-67400 Illkirch Graffenstaden, France

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 47卷 / 06期

关键词：

D O I：

10.1021/jm030480f

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：1303 / 1314

页数：12

共 85 条

[1]

AMSCHLER H, Patent No. 8816264

[2]

Aulabaugh Ann, 2000, Drugs of the Future, V25, P287, DOI 10.1358/dof.2000.025.03.572014

[3] A NEW CLASS OF SYMPATHETIC BETA-RECEPTOR BLOCKING AGENTS - 3,4-DIHYDRO-3-HYDROXY-1,5-BENZOXAZOCINES [J].

BASIL, B ;

COFFEE, ECJ ;

GELL, DL ;

MAXWELL, DR ;

SHEFFIEL.DJ ;

WOOLDRID.KR .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (03) :403-&

[4] (2-methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors [J].

Baumgarth, M ;

Beier, N ;

Gericke, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (13) :2017-2034

[5] Discovering transthyretin amyloid fibril inhibitors by limited screening [J].

Baures, PW ;

Peterson, SA ;

Kelly, JW .

BIOORGANIC & MEDICINAL CHEMISTRY, 1998, 6 (08) :1389-1401

[6] Hit-to-lead studies: The discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists [J].

Baxter, A ;

Bennion, C ;

Bent, J ;

Boden, K ;

Brough, S ;

Cooper, A ;

Kinchin, E ;

Kindon, N ;

McInally, T ;

Mortimore, M ;

Roberts, B ;

Unitt, J .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (16) :2625-2628

[7] CYCLIC ADENOSINE MONOPHOSPHATE PHOSPHODIESTERASE IN BRAIN - EFFECT ON ANXIETY [J].

BEER, B ;

CHASIN, M ;

VOGEL, JR ;

CLODY, DE ;

HOROVITZ, ZP .

SCIENCE, 1972, 176 (4033) :428-+

[8] Absorption classification of oral drugs based on molecular surface properties [J].

Bergström, CAS ;

Strafford, M ;

Lazorova, L ;

Avdeef, A ;

Luthman, K ;

Artursson, P .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (04) :558-570

[9] (+)-NIGULDIPINE BINDS WITH VERY HIGH-AFFINITY TO CA-2+ CHANNELS AND TO A SUBTYPE OF ALPHA-1-ADRENOCEPTORS [J].

BOER, R ;

GRASSEGGER, A ;

SCHUDT, C ;

GLOSSMANN, H .

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1989, 172 (02) :131-145

[10] Inhibition of I-Ks in guinea pig cardiac myocytes and guinea pig I-sK channels by the chromanol 293B [J].

Busch, AE ;

Suessbrich, H ;

Waldegger, S ;

Sailer, E ;

Greger, R ;

Lang, HJ ;

Lang, F ;

Gibson, KJ ;

Maylie, JG .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1996, 432 (06) :1094-1096

← 1 2 3 4 5 6 7 8 9 →