Recruitment strategies in superiority trials in SLE: lessons from the study of methotrexate in lupus erythematosus (SMILE)

被引:8
作者
Ferland, D
Fortin, PR
机构
[1] McGill Univ, Div Clin Epidemiol, Montreal Gen Hosp, Dept Med,Res Inst,Hlth Ctr, Montreal, PQ H3G 1A4, Canada
[2] McGill Univ, Dept Med, Montreal Gen Hosp, Div Rheumatol,Res Inst,Hlth Ctr, Montreal, PQ H3G 1A4, Canada
关键词
recruitment strategies; SLE; problems with recruitment;
D O I
10.1191/096120399680411371
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The task of recruiting patients for a research project can prove to be the most difficult aspect of the entire research process. A large portion of the work of research is devoted to the identification of strategies which ensure a successful recruitment of patients. Every researcher has learned from experience the many methods needed to enhance patient enrollment into trials. Superiority trials in SLE have not been frequent in previous years. This paper describes the challenges encountered with the multicentre SMILE trial in progress across Canada. We identify areas where patient recruitment is a problem, potential reasons for the problem, and the results of tactics used to increase enrollment.
引用
收藏
页码:606 / 611
页数:6
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