Questioning the role of rebound firing in the cerebellum

被引：86

作者：

Alvina, Karina ^{[1
,2
]}

Walter, Joy T. ^{[1
]}

Kohn, Adam ^{[1
]}

Ellis-Davies, Graham ^{[3
]}

Khodakhah, Kamran ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Bronx, NY 10461 USA

[2] Pontificia Univ Catolica Chile, Dept Ciencias Fisiol, Santiago, Chile

[3] Drexel Univ, Coll Med, Dept Physiol & Pharmacol, Philadelphia, PA 19102 USA

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nn.2195

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A key component of recent theories on cerebellar function is rebound firing in neurons of the deep cerebellar nuclei (DCN). Despite the robustness of this phenomenon in vitro, in vivo studies have provided little evidence for its prevalence. We found that intact mouse or rat DCN neurons rarely showed rebound firing under physiological conditions in vitro or in vivo. These observations necessitate a critical re-evaluation of recent cerebellar models.

引用

页码：1256 / 1258

页数：3

共 15 条

[1] Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum [J].

Aizenman, CD ;

Linden, DJ .

JOURNAL OF NEUROPHYSIOLOGY, 1999, 82 (04) :1697-1709

[2] Polarity of long-term synaptic gain change is related to postsynaptic spike firing at a cerebellar inhibitory synapse [J].

Aizenman, CD ;

Manis, PB ;

Linden, DJ .

NEURON, 1998, 21 (04) :827-835

[3] GABA neurotransmission in the cerebellar interposed nuclei: Involvement in classically conditioned eyeblinks and neuronal activity [J].

Aksenov, D ;

Serdyukova, N ;

Irwin, K ;

Bracha, V .

JOURNAL OF NEUROPHYSIOLOGY, 2004, 91 (02) :719-727

[4] Firing activities of identified posterior interpositus nucleus neurons during associative learning in behaving cats [J].

Delgado-García, JM ;

Gruart, A .

BRAIN RESEARCH REVIEWS, 2005, 49 (02) :367-376

[5] Movement-related discharge in the cerebellar nuclei persists after local injections of GABAA antagonists [J].

Holdefer, RN ;

Houk, JC ;

Miller, LE .

JOURNAL OF NEUROPHYSIOLOGY, 2005, 93 (01) :35-43

[6]

Ito M., 1984, CEREBELLUM NEURAL CO

[7]

JAHNSEN H, 1986, J PHYSIOL-LONDON, V372, P129, DOI 10.1113/jphysiol.1986.sp016001

[8] Time windows and reverberating loops: a reverse-engineering approach to cerebellar function [J].

Kistler, WM ;

De Zeeuw, CI .

CEREBELLUM, 2003, 2 (01) :44-54

[9] Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2 [J].

Lee, Henry H. C. ;

Walker, Joshua A. ;

Williams, Jeffery R. ;

Goodier, Richard J. ;

Payne, John A. ;

Moss, Stephen J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (41) :29777-29784

[10] ELECTROPHYSIOLOGY OF GUINEA-PIG CEREBELLAR NUCLEAR-CELLS IN THE INVITRO BRAIN-STEM CEREBELLAR PREPARATION [J].

LLINAS, R ;

MUHLETHALER, M .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 404 :241-258

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