A blue-light-activated adenylyl cyclase mediates photoavoidance in Euglena gracilis

被引:379
作者
Iseki, M
Matsunaga, S
Murakami, A
Ohno, K
Shiga, K
Yoshida, K
Sugai, M
Takahashi, T
Hori, T
Watanabe, M [1 ]
机构
[1] Natl Inst Basic Biol, Okazaki 4448585, Japan
[2] Biooriented Technol Res Advancement Inst, Minato Ku, Tokyo 1050001, Japan
[3] Nagoya Univ, Ctr Gene Res, Chikusa Ku, Nagoya, Aichi 4648602, Japan
[4] Univ Tsukuba, Inst Biol Sci, Tsukuba, Ibaraki 3058572, Japan
[5] Kobe Univ, Res Ctr Inland Seas, Awaji, Hyogo 6562401, Japan
[6] Kumamoto Univ, Sch Med, Dept Physiol, Kumamoto 8608556, Japan
[7] Toyama Univ, Fac Sci, Dept Biol, Toyama 9308555, Japan
[8] Toho Univ, Sch Pharmaceut Sci, Chiba 2748510, Japan
[9] Grad Univ Adv Studies, Sch Adv Sci, Dept Photosci, Kanagawa 2400193, Japan
关键词
D O I
10.1038/4151047a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Blue light regulates processes such as the development of plants and fungi and the behaviour of microbes(1,2). Two types of blue-light receptor flavoprotein have been identified: cryptochromes, which have partial similarity to photolyases(3,4), and phototropins, which are photoregulated protein kinases(5,6). The former have also been found in animals with evidence of essential roles in circadian rhythms(7,8). Euglena gracilis, a unicellular flagellate, abruptly changes its swimming direction after a sudden increase or decrease in incident blue light intensity, that is, step-up or step-down photophobic responses, resulting in photoavoidance or photoaccumulation, respectively(9). Although these photobehaviours of Euglena have been studied for a century(10), the photoreceptor molecules mediating them have remained unknown(9). Here we report the discovery and biochemical characterization of a new type of blue-light receptor flavoprotein, photoactivated adenylyl cyclase, in the photoreceptor organelle of Euglena gracilis, with molecular genetic evidence that it mediates the step-up photophobic response.
引用
收藏
页码:1047 / 1051
页数:5
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