Novel Strategies to Improve the Anticancer Action of 5-Fluorouracil by Using Drug Delivery Systems

被引：186

作者：

Arias, Jose L. ^{[1
]}

机构：

[1] Univ Granada, Fac Pharm, Dept Pharm & Pharmaceut Technol, E-18071 Granada, Spain

来源：

MOLECULES | 2008年 / 13卷 / 10期

关键词：

Biodegradable polymers; Cancer treatment; Drug carriers; 5-Fluorouracil; Vesicular systems;

D O I：

10.3390/molecules13102340

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Because of the fundamental importance of new therapeutic routes for cancer treatment, a number of systems based on colloidal particles as vehicles for the delivery of the anticancer drug 5-fluorouracil have been devised. The target is always to provide the proper dose of the antitumor agent only at the desired locus of action, thus reducing the unwanted side effects. In this review, the main strategies and the more significant results in the development of 5-fluorouracil carriers for cancer treatment are discussed.

引用

页码：2340 / 2369

页数：30

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