Metallophosphites as umpolung catalysts: The enantioselective cross silyl benzoin reaction

被引：134

作者：

Xin, LH ^{[1
]}

Potnick, JR ^{[1
]}

Johnson, JS ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 10期

关键词：

D O I：

10.1021/ja0496468

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carbonyl polarity reversal (umpolung) has been realized employing metallophosphites as catalysts. As a result, nonenzymatic asymmetric cross silyl benzoin reactions have been achieved, giving optically active silyl ether-protected benzoin adducts. The reaction is general with respect to aryl, alkyl, and heterocyclic substrates with good to excellent yields and good to excellent enantioselectivities. Copyright © 2004 American Chemical Society.

引用

页码：3070 / 3071

页数：2

共 27 条

[1] ASYMMETRIC-SYNTHESIS OF ALPHA-HYDROXY-PHOSPHONAMIDES, PHOSPHONATES AND PHOSPHONIC-ACIDS [J].