Fluctuations in plasma macrophage colony-stimulating factor levels during autologous peripheral blood stem cell transplantation for haematologic diseases

被引：2

作者：

Saigo, K

Sugimoto, T

Matsui, T

Ryo, R

Kumagai, S

机构：

[1] Kobe Univ Hosp, Div Blood Transfus, Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Kobe Kyodo Hosp, Sect Internal Med, Kobe, Hyogo, Japan

[3] Kobe Univ, Sch Med, Dept Haematol, Kobe, Hyogo 650, Japan

[4] Kobe Univ, Sch Med, Fac Hlth Sci, Kobe, Hyogo 650, Japan

来源：

CLINICAL AND LABORATORY HAEMATOLOGY | 2002年 / 24卷 / 01期

关键词：

M-CSF; peripheral blood stem cell transplantation; endothelial cells; thrombomodulin;

D O I：

10.1046/j.1365-2257.2002.00156.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma macrophage colony-stimulating factor (M-CSF) levels were measured in 13 haematologic patients treated with autologous peripheral blood stem cell transplantation (PBSCT). Six of the patients showed an increase in M-CSF peak levels (> 3000 pg/ml) during the conditioning and stem cell infusion period. The peak levels of M-CSF in this phase correlated with thrombomodulin levels, indicating the endothelial origin of plasma M-CSF. However, the M-CSF levels were not influenced by TNFalpha. More patients with high M-CSF levels (> 5000 pg/ml) suffered from organ failure than those with lower M-CSF levels. These results suggest that high M-CSF levels may correlate with cellular or organ damage in patients treated with PBSCT.

引用

页码：37 / 42

页数：6

共 19 条

[1] Effect of cytokines and growth factors on the macrophage colony-stimulating factor secretion by human bone marrow stromal cells [J].