Decreased integrin gene expression in patients with MS responding to interferon-β treatment

被引：35

作者：

Muraro, PA

Liberati, L

Bonanni, L

Pantalone, A

Caporale, CM

Iarlori, C

De Luca, G

Farina, D

Lugaresi, A

Gambi, D

机构：

[1] NINDS, Neuroimmunol Branch, Bethesda, MD 20892 USA

[2] Univ Annunzio, Med Sch, Dept Oncol & Neurosci, Neuroimmunol Unit, I-66013 Chieti, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 150卷 / 1-2期

关键词：

multiple sclerosis; interferon-beta; adhesion molecules; VLA-4; LFA-1;

D O I：

10.1016/j.jneuroim.2004.01.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interferon-beta (IFN-beta) ameliorates disease course in a subset of patients with MS. The reasons for heterogeneity of clinical responses, however, are unclear. We assessed possible effects of IFN-beta on the gene expression of the leukocyte adhesion molecules VLA-4 and LFA-1 during the first year of treatment of 50 patients with relapsing-remitting MS who showed differential clinical responses. We observed a significant reduction of VLA-4 (P=0.002) and LFA-1 (P=0.03) mRNA expression compared to baseline in first-year clinical responders (n=22). In contrast, first-year IFN-beta non-responders (n=28) had unchanged levels of VLA-4 and LFA-1. In vitro treatment of PBMC with IFN-beta indicated a direct effect on transcription of the integrins' genes. Transcriptional downmodulation of adhesion molecules during IFN-beta treatment may contribute to its mode of action in MS. (C) 2004 Elsevier B.V. All rights reserved.

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页码：123 / 131

页数：9

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